An ionizable cationic lipid
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L202

Item No. 37841

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-methyl-4-piperidinecarboxylic acid, 2-[9-oxo-9-[(3-pentyloctyl)oxy]nonyl]dodecyl ester
CAS Number
2170488-92-1
Molecular Formula
C41H79NO4
Formula Weight
650.1
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble
SMILES
CCCCCC(CCCCC)CCOC(CCCCCCCCC(COC(C1CCN(CC1)C)=O)CCCCCCCCCC)=O
InChi Code
InChI=1S/C41H79NO4/c1-5-8-11-12-13-14-17-22-27-38(36-46-41(44)39-30-33-42(4)34-31-39)28-23-18-15-16-19-24-29-40(43)45-35-32-37(25-20-9-6-2)26-21-10-7-3/h37-39H,5-36H2,1-4H3
InChi Key
JMCDZNNKPXAYBZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $125

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    5 mg

    $433

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    10 mg

    $742

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    Cayman Chemical
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    Product Description

    L202 is an ionizable cationic lipid (pKa = 6.04) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA.1 Intramuscular administration of LNPs containing L202 and encapsulating nucleoside-modified mRNA encoding pre-fusion stabilized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein, also known as surface glycoprotein, increase plasma levels of IgG antibodies targeting SARS-CoV-2 spike glycoprotein in mice and cynomolgus monkeys.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Suzuki, Y., Miyazaki, T., Muto, H., et al. Design and lyophilization of lipid nanoparticles for mRNA vaccine and its robust immune response in mice and nonhuman primates. Mol. Ther. Nucleic Acids 30, 226-240 (2022).