An inhibitor of ecto-5’-nucleotidase
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ZM 522

Item No. 37904

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3β-[(4-fluorobenzoyl)oxy]-lup-20(29)-en-28-oic acid
CAS Number
1454575-38-2
Molecular Formula
C37H51FO4
Formula Weight
578.8
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 2 mg/mlEthanol: 2 mg/ml
λmax
241 nm
SMILES
C[C@]1([C@]2([C@]([C@@]3([C@@](C(C)([C@H](CC3)OC(C4=CC=C(F)C=C4)=O)C)([H])CC2)C)([H])CC5)C)[C@@]5([H])[C@]([C@@H](CC6)C(C)=C)([H])[C@@]6(C(O)=O)CC1
InChi Code
InChI=1S/C37H51FO4/c1-22(2)25-14-19-37(32(40)41)21-20-35(6)26(30(25)37)12-13-28-34(5)17-16-29(33(3,4)27(34)15-18-36(28,35)7)42-31(39)23-8-10-24(38)11-9-23/h8-11,25-30H,1,12-21H2,2-7H3,(H,40,41)/t25-,26+,27-,28+,29-,30+,34-,35+,36+,37-/m0/s1
InChi Key
YVDDYENCDWEHSB-DWKDZXJCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $40

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    50 mg

    $69

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    100 mg

    $127

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    Product Description

    ZM 522 is an inhibitor of ecto-5'-nucleotidase, also known as CD73 (IC50s = 0.56 and 3.06 µM for the human and mouse enzymes, respectively), and a derivative of the triterpenoid betulinic acid (Item No. 11686).1 It increases the levels of IFN-γ secreted by isolated mouse spleen cells when used at a concentration of 10 µM in the presence of AMP.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, Y., Yang, K., Ye, S., et al. Application of a fluorine strategy in the lead optimization of betulinic acid to the discovery of potent CD73 inhibitors. Steroids 188, 109112 (2022).