A modified nucleoside
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

5-methyl-2'-O-Methylcytidine

Item No. 37908

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-methyl-2′-O-methyl-cytidine
CAS Number
113886-70-7
Synonyms
  • m5Cm
  • 2'-O-Methyl-5-methyl-cytosine
Molecular Formula
C11H17N3O5
Formula Weight
271.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
282 nm
SMILES
CC(C(N)=N1)=CN([C@H]2[C@H](OC)[C@H](O)[C@@H](CO)O2)C1=O
InChi Code
InChI=1S/C11H17N3O5/c1-5-3-14(11(17)13-9(5)12)10-8(18-2)7(16)6(4-15)19-10/h3,6-8,10,15-16H,4H2,1-2H3,(H2,12,13,17)/t6-,7-,8-,10-/m1/s1
InChi Key
CNVRVGAACYEOQI-FDDDBJFASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    50 mg

    $79

    Add

    100 mg

    $148

    Add

    250 mg

    $272

    Add

    500 mg

    $466

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    5-methyl-2'-O-Methylcytidine is a modified nucleoside that has been found in S. solfataricus, T. neutrophilus, and P. occultum tRNA. 1 It is found in Huh7 cells infected with Zika virus, hepatitis C virus (HCV), poliovirus, or HIV-1 provirus but not uninfected Huh7 cells.2 5-methyl-2'-O-Methylcytidine (4 µg/ml) inhibits IL-12 and IL-6 release induced by a toll-like receptor 9 (TLR9) agonist, an unmethylated CpG oligodeoxynucleotide, in mouse spleen cell cultures.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Edmonds, C.G., Crain, P.F., Hashizume, T., et al. Structural characterization of four ribose-methylated nucleosides from the transfer RNA of extremely thermophilic archaebacteria. J. Chem. Soc. Chem. Commun. 12, 909-910 (1987).

    2. McIntyre, W., Netzband, R., Bonenfant, G., et al. Positive-sense RNA viruses reveal the complexity and dynamics of the cellular and viral epitranscriptomes during infection. Nucleic Acids Res. 46(11), 5776-5791 (2018).

    3. Yu, D., Wang, D., Zhu, F.-G., et al. Modifications incorporated in CpG motifs of oligodeoxynucleotides lead to antagonist activity of toll-like receptors 7 and 9. J. Med. Chem. 52(16), 5108-5114 (2009).