An ionizable cationic lipid
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Lipid 2,2(8,8) 4C CH3

Item No. 37910

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
heptadecan-9-yl (Z)-N-(((4-(dimethylamino)butyl)thio)carbonyl)-N-(2-(non-2-en-1-yloxy)-2-oxoethyl)glycinate
CAS Number
2230647-30-8
Synonyms
  • ATX-0114
Molecular Formula
C37H70N2O5S
Formula Weight
655.0
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMSO: SolubleEthanol: SolubleMethanol: Soluble
SMILES
O=C(SCCCCN(C)C)N(CC(OC/C=C\CCCCCC)=O)CC(OC(CCCCCCCC)CCCCCCCC)=O
InChi Code
InChI=1S/C37H70N2O5S/c1-6-9-12-15-18-21-25-30-43-35(40)32-39(37(42)45-31-26-24-29-38(4)5)33-36(41)44-34(27-22-19-16-13-10-7-2)28-23-20-17-14-11-8-3/h21,25,34H,6-20,22-24,26-33H2,1-5H3/b25-21-
InChi Key
ZPTCRTNVBPVOIQ-DAFNUICNSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $351

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    25 mg

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    Product Description

    Lipid 2,2(8,8) 4C CH3 is an ionizable cationic lipid (pKa = 6.69).1 It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA in vivo. LNPs containing lipid 2,2(8,8) 4C CH3 and encapsulating siRNA targeting Factor VII decrease plasma Factor VII protein levels by 90% in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Payne, J.E., Chivukula, P., Tanis, S.P., et al. Ionizable cationic lipid for RNA delivery. (2018).