An ionizable cationic lipid
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306-N16B

Item No. 37927

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,3',3'',3'''-(((methylazanediyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrakis(N-(2-(dodecyldisulfaneyl)ethyl)propanamide)
CAS Number
2803699-70-7
Molecular Formula
C75H151N7O4S8
Formula Weight
1471.6
Purity
≥95%
Formulation (Request formulation change)
A 5 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
Ethanol: SolubleMethanol: Soluble
SMILES
CN(CCCN(CCC(NCCSSCCCCCCCCCCCC)=O)CCC(NCCSSCCCCCCCCCCCC)=O)CCCN(CCC(NCCSSCCCCCCCCCCCC)=O)CCC(NCCSSCCCCCCCCCCCC)=O
InChi Code
InChI=1S/C75H151N7O4S8/c1-6-10-14-18-22-26-30-34-38-42-64-87-91-68-52-76-72(83)48-60-81(61-49-73(84)77-53-69-92-88-65-43-39-35-31-27-23-19-15-11-7-2)58-46-56-80(5)57-47-59-82(62-50-74(85)78-54-70-93-89-66-44-40-36-32-28-24-20-16-12-8-3)63-51-75(86)79-55-71-94-90-67-45-41-37-33-29-25-21-17-13-9-4/h6-71H2,1-5H3,(H,76,83)(H,77,84)(H,78,85)(H,79,86)
InChi Key
VXYBSHYDQFZZLQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    500 µg

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    Cayman Chemical
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    Product Description

    306-N16B is an ionizable cationic lipid.1 It has been used in the generation of lipid nanoparticles (LNPs). LNPs containing 306-N16B and encapsulating an mRNA reporter accumulate specifically in the mouse lung, primarily in lung endothelial cells, after intravenous administration. LNPs containing both 306-N16B and 306-O12B (Item No. 37549) and encapsulating mRNA encoding tuberous sclerosis complex 2 (Tsc2), a tumor suppressor, reduce tumor growth in a mouse model of pulmonary lymphangioleiomyomatosis (LAM) induced by intravenous injection of Tsc2-null kidney-derived epithelial tumor cells (TTJ cells).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Qiu, M., Tang, Y., Chen, J., et al. Lung-selective mRNA delivery of synthetic lipid nanoparticles for the treatment of pulmonary lymphangioleiomyomatosis. Proc. Natl. Acad. Sci. USA 119(8), e2116271119 (2022).