A genotoxic gut microbiota metabolite
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Indolimine-214

Item No. 37953

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(E)-1-(1H-indol-3-yl)-N-isopentylmethanimine
Synonyms
  • Isoamylindolimine
Molecular Formula
C14H18N2
Formula Weight
214.3
Purity
≥98%
Formulation (Request formulation change)
A neat solid
Solubility(Learn about Variance in Solubility)
Methanol: Soluble
λmax
220, 260, 272, 293 nm
SMILES
CC(C)CC/N=C/C1=CNC2=C1C=CC=C2
InChi Code
InChI=1S/C14H18N2/c1-11(2)7-8-15-9-12-10-16-14-6-4-3-5-13(12)14/h3-6,9-11,16H,7-8H2,1-2H3/b15-9+
InChi Key
PRZNKSWHLNOJKF-OQLLNIDSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $29

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    5 mg

    $128

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    10 mg

    $225

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    Cayman Chemical
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    Product Description

    Indolimine-214 is a metabolite of M. morganii, a bacterium that is increased in the gut microbiome of patients with inflammatory bowel disease (IBD) and colorectal cancer (CRC).1 Indolimine-214 (25 and 100 µg/ml) increases γH2AX levels in HeLa cells and increases the tail DNA percentage in a comet assay using HeLa cells when used at a concentration of 100 µg/ml, both markers of DNA damage, but does not induce DNA damage when used alone in a circular pUC19 plasmid-based genotoxicity assay.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cao, Y., Oh, J., Xue, M., et al. Commensal microbiota from patients with inflammatory bowel disease produce genotoxic metabolites. Science 378(6618), eabm3233 (2022).