Host: E. coli • AA: 17-138 • MW: 13.8 kDa
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Product Categories

Product Type

Proteins

Research Area

Lipid Biochemistry
Glycerophospholipids
Phospholipases

Basic PLA2 homolog MjTX-I (Bothrops moojeni, recombinant)

Item No. 37957

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Basic Phospholipase A2 homolog 1
  • Basic PLA2 homolog BomoTx
  • B. moojeni Myotoxin I
  • svPLA2 homolog
Purity
≥85% estimated by SDS-PAGE
Source
Recombinant Brazilian lancehead viper (B. moojeni) PLA2 expressed in E. coli
Amino Acids
17-138
MW
13.8 kDa
Formulation (Request formulation change)
50 mM Tris-HCl, pH 8.0, with 100 mM sodium chloride
UniProt Accession №
P82114
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    25 µg

    $141

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    Product Description

    Basic phospholipase A2 (PLA2) homolog MjTX-I is a PLA2-like myotoxin of the Lys49-PLA2 family that has been found in Brazilian lancehead viper (B. moojeni) venom.1 Unlike other Lys49-PLA2 proteins that form homodimers, basic PLA2 homolog MjTX-I forms oligomeric conformations in solution that can also be induced by certain ligands such as the class 3 PLA2-like toxin inhibitor suramin (Item No. 11126).2,1,3 Basic PLA2 homolog MjTX-I is catalytically inactive and has lower myotoxic activity than other Lys49-PLA2 proteins in mice.2,1 It is cytotoxic to myoblasts in vitro and intraperitoneally lethal to mice.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Salvador, G.H.M., Dreyer, T.R., Gomes, A.A.S., et al. Structural and functional characterization of suramin-bound MjTX-I from Bothrops moojeni suggests a particular myotoxic mechanism. Sci. Rep. 8(1), 10317 (2018).

    2. Salvador, G.H.M., Fernandes, C.A.H., Magro, A.J., et al. Structural and phylogenetic studies with MjTX-I reveal a multi-oligomeric toxin - a novel feature in Lys49-PLA2s protein class. PLOS One 8(4), e60610 (2013).

    3. Salvador, G.H.M., Gomes, A.A.S., Bryan-Quirós, W., et al. Structural basis for phospholipase A2-like toxin inhibition by the synthetic compound Varespladib (LY315920). Sci. Rep. 9(1), 17203 (2019).

    4. Soares, A.M., Andrião-Escarso, S.H., Lomonte, Y.A.B., et al. Structural and functional characterization of myotoxin I, a Lys49 phospholipase A2 homologue from Bothrops moojeni (Caissaca) snake venom. Arch. Biochem. Biophys. 373(1), 7-15 (2000).