An ionizable cationic lipid
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IC8

Item No. 37986

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,1',1'',1'''-((piperazine-1,4-diylbis(propane-3,1-diyl))bis(azanetriyl))tetrakis(tetradecan-2-ol)
CAS Number
2349307-32-8
Molecular Formula
C66H136N4O4
Formula Weight
1049.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: Slightly solubleDMSO: Slightly soluble
SMILES
OC(CCCCCCCCCCCC)CN(CC(CCCCCCCCCCCC)O)CCCN1CCN(CCCN(CC(CCCCCCCCCCCC)O)CC(CCCCCCCCCCCC)O)CC1
InChi Code
InChI=1S/C66H136N4O4/c1-5-9-13-17-21-25-29-33-37-41-47-63(71)59-69(60-64(72)48-42-38-34-30-26-22-18-14-10-6-2)53-45-51-67-55-57-68(58-56-67)52-46-54-70(61-65(73)49-43-39-35-31-27-23-19-15-11-7-3)62-66(74)50-44-40-36-32-28-24-20-16-12-8-4/h63-66,71-74H,5-62H2,1-4H3
InChi Key
FTGMRNQBRRDPKP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

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    Cayman Chemical
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    Product Description

    IC8 is an ionizable cationic lipid.1,2 It has been used in combination with other lipids for the formation of lipid nanoparticles (LNPs). Immunization with severe acute respiratory coronavirus 2 (SARS-CoV-2) spike glycoprotein mRNA in IC8- and manganese-containing LNPs induces IgG responses to SARS-CoV-2 Delta and Omicron variants in mice.1 Administration of mRNA encoding B7-H3 X CD3 bispecific T cell engaging (BiTE) antibodies in IC8-containing LNPs reduces tumor growth in MV4-11 and A375 mouse xenograft models.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fan, N., Chen, K., Zhu, R., et al. Manganese-coordinated mRNA vaccines with enhanced mRNA expression and immunogenicity induce robust immune responses against SARS-CoV-2 variants. Sci. Adv. 8(51), eabq3500 (2022).

    2. Huang, C., Duan, X., Wang, J., et al. Lipid nanoparticle delivery system for mRNA encoding B7H3-redirected bispecific antibody displays potent antitumor effects on malignant tumors. Adv. Sci. (Weinh) Online ahead of print, e2205532 (2022).