An ionizable cationic lipid
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Lipid OA2 (hydrochloride)

Item No. 37987

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
di((Z)-octadec-9-en-1-yl) L-lysyl-L-glutamate, dihydrochloride
Synonyms
  • KE-oleyl
Molecular Formula
C47H89N3O5 • 2HCl
Formula Weight
849.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Soluble
SMILES
NCCCC[C@@H](C(N[C@@H](CCC(OCCCCCCCC/C=C\CCCCCCCC)=O)C(OCCCCCCCC/C=C\CCCCCCCC)=O)=O)N.Cl.Cl
InChi Code
InChI=1S/C47H89N3O5.2ClH/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-35-41-54-45(51)39-38-44(50-46(52)43(49)37-33-34-40-48)47(53)55-42-36-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;;/h17-20,43-44H,3-16,21-42,48-49H2,1-2H3,(H,50,52);2*1H/b19-17-,20-18-;;/t43-,44-;;/m0../s1
InChi Key
DBWZQQDZKDSHKF-CTLKWHTASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $105

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    10 mg

    $200

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    25 mg

    $418

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    50 mg

    $785

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    Cayman Chemical
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    Product Description

    Lipid OA2 is an ionizable cationic lipid that has been used in the generation of single-component lipid nanoparticles (LNPs) for the delivery of siRNA.1 LNPs containing lipid OA2 and siRNA targeting the gene encoding suppressor of cytokine signaling 1 (Socs1) decrease Socs1 expression by approximately 50% in isolated mouse bone marrow dendritic cells (BMDCs). Vaccination with ovalbumin-induced isolated mouse BMDCs transfected with LNPs composed of lipid OA2 and Socs1-targeting siRNA increases survival and decreases tumor volume in a B16-OVA murine melanoma model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yu, Z., Wu, M., Huang, Y., et al. Single-component lipid nanoparticles for engineering SOCS1 gene-silenced dendritic cells to boost tumor immunotherapy. Biomater. Sci. 11(1), 263-277 (2023).