A STING agonist
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BSP-16

Item No. 37992

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
αR-ethyl-5,6-dimethoxy-γ-oxo-benzo[b]selenophene-2-butanoic acid
CAS Number
2727249-47-8
Synonyms
  • LF250
Molecular Formula
C16H18O5Se
Formula Weight
369.3
Purity
≥98%
Formulation
A solid
λmax
218, 332 nm
SMILES
O=C(C[C@@H](CC)C(O)=O)C1=CC2=CC(OC)=C(OC)C=C2[Se]1
InChi Code
InChI=1S/C16H18O5Se/c1-4-9(16(18)19)5-11(17)15-7-10-6-12(20-2)13(21-3)8-14(10)22-15/h6-9H,4-5H2,1-3H3,(H,18,19)/t9-/m1/s1
InChi Key
BWQHPFYQJHFPHN-SECBINFHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $168

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    1 mg

    $318

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    5 mg

    $1,088

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    Cayman Chemical
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    Product Description

    BSP-16 is a stimulator of interferon genes (STING) agonist.1 It binds to STING (Kd = 23 µM) and induces the production of IFN-β, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1 cells when used at concentrations of 10, 25, and 50 µM. BSP-16 (50 µM) induces phosphorylation of IFN regulatory factor 3 (IRF3) and TANK-binding kinase 1 (TBK1) in THP-1 cells. In vivo, BSP-16 (15 and 30 mg/kg) reduces tumor volume in an MC-38 murine carcinoma model and induces tumor regression in a CT26 murine colorectal carcinoma model. It prevents tumor cell re-challenge-induced tumor formation in a CT26 murine carcinoma model. BSP-16 (20 mg/kg) also reduces tumor volume and increases the number of activated CD8+ T cells and natural killer (NK) cells in a 4T1 murine mammary carcinoma model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Feng, X., Pan, L., Qian, Z., et al. Discovery of selenium-containing STING agonists as orally available antitumor agents. J. Med. Chem. 65(22), 15048-15065 (2022).