An ionizable cationic amino lipid
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AL-A12

Item No. 38001

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-dodecyl-N-(3-methoxypropyl)-1-dodecanamine
CAS Number
3037065-56-5
Molecular Formula
C28H59NO
Formula Weight
425.8
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: 10 mg/ml
SMILES
CCCCCCCCCCCCN(CCCOC)CCCCCCCCCCCC
InChi Code
InChI=1S/C28H59NO/c1-4-6-8-10-12-14-16-18-20-22-25-29(27-24-28-30-3)26-23-21-19-17-15-13-11-9-7-5-2/h4-28H2,1-3H3
InChi Key
XIJJLFBIFPWYLH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $79

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    5 mg

    $329

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    10 mg

    $543

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    Cayman Chemical
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    Product Description

    AL-A12 is an ionizable cationic amino lipid that has been used in the formation of lipid nanoparticles (LNPs).1 LNPs containing AL-A12 and encapsulating minicircle DNA that encodes for GFP have been used to induce GFP expression in Huh7 cells. LNPs containing AL-A12 and encapsulating DNA that encodes for RFP have been used to induce RFP expression in endothelial cells and venous vasculature in a zebrafish embryo model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Buck, J., Mueller, D., Mettal, U., et al. Improvement of DNA vector delivery of DOTAP lipoplexes by short-chain aminolipid. ACS Omega 5(38), 24724-24732 (2020).