A ferroptosis inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

YL-939

Item No. 38006

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-(3,6-dihydro-2H-pyran-4-yl)-2-phenyl-6-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-imidazo[1,2-a]pyrazine
CAS Number
3023925-68-7
Molecular Formula
C25H26N6O
Formula Weight
426.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Slightly soluble: 0.1-1 mg/mlWater: Slightly soluble: 0.1-1 mg/ml
SMILES
C(N=C1C2=CCOCC2)(C3=CN(C4CCNCC4)N=C3)=CN5C1=NC(C6=CC=CC=C6)=C5
InChi Code
InChI=1S/C25H26N6O/c1-2-4-18(5-3-1)22-16-30-17-23(20-14-27-31(15-20)21-6-10-26-11-7-21)28-24(25(30)29-22)19-8-12-32-13-9-19/h1-5,8,14-17,21,26H,6-7,9-13H2
InChi Key
CQPPSOHBTWZQRN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $86

    Add

    5 mg

    $237

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    YL-939 is an inhibitor of ferroptosis.1 It inhibits erastin-induced increases in ferrous iron levels and ferroptosis in ES-2 ovarian cancer cells when used at a concentration of 0.3 µM. YL-939 (10 µM) increases nuclear receptor coactivator 4 (NCOA4) and ferritin levels in ES-2 cells. In vivo, YL-939 (3 mg/kg) decreases serum alanine transaminase (Alt) and aspartate aminotransferase (Ast) levels, reduces liver and serum malondialdehyde (MDA) levels, and increases liver ferritin levels in a mouse model of acetaminophen-induced acute liver injury.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yang, W., Mu, B., You, J., et al. Non-classical ferroptosis inhibition by a small molecule targeting PHB2. Nat. Commun. 13(1), 7473 (2022).