A PAD2 inhibitor
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CAY10723 (hydrochloride)

Item No. 38018

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(1S)-4-[(2-fluoro-1-iminoethyl)amino]-1-(4-methoxy-1-methyl-1H-benzimidazol-2-yl)butyl]-2,3-dihydro-3-oxo-1H-isoindole-4-carboxamide, monohydrochloride
Synonyms
  • AFM30a
  • AMF30a
Molecular Formula
C24H27FN6O3 • HCl
Formula Weight
503.0
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 5 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O=C(N[C@@H](CCCNC(CF)=N)C1=NC2=C(C=CC=C2OC)N1C)C3=C(C(NC4)=O)C4=CC=C3.Cl
InChi Code
InChI=1S/C24H27FN6O3.ClH/c1-31-17-9-4-10-18(34-2)21(17)30-22(31)16(8-5-11-27-19(26)12-25)29-23(32)15-7-3-6-14-13-28-24(33)20(14)15;/h3-4,6-7,9-10,16H,5,8,11-13H2,1-2H3,(H2,26,27)(H,28,33)(H,29,32);1H/t16-;/m0./s1
InChi Key
HDGZNBCVLSJSHI-NTISSMGPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    5 mg

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    Cayman Chemical
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    Product Description

    CAY10723 is an inhibitor of peptidyl arginine deiminase 2 (PAD2; EC50 = 9.5 μM in a cellular target engagement assay).1 It is approximately 1.6-, 47-, and 15-fold selective for PAD2 over PAD1, PAD3, and PAD4, respectively. CAY10723 inhibits histone H3 citrullination in HEK293T cells expressing human PAD2 (EC50 = 0.4 μM). It also inhibits fibrinogen citrullination in the presence of isolated human polymorphonuclear leukocytes (PMNs) or synovial fluid from patients with rheumatoid arthritis when used at a concentration of 20 µM.2 CAY10723 (25 µM) decreases IFN-γ production in isolated human CD4+ T cells.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Muth, A., Subramanian, V., Beaumont, E., et al. Development of a selective inhibitor of protein arginine deiminase 2. J. Med. Chem. 60(7), 3198-3211 (2017).

    2. Monreal, M.T.M., Rebak, A.S., Massarenti, L., et al. Applicability of small-molecule inhibitors in the study of peptidyl arginine deiminase 2 (PAD2) and PAD4. Front. Immunol. 12, 716250 (2021).

    3. Liu, Y., Lightfood, Y.L., Seto, N., et al. Peptidylarginine deiminases 2 and 4 modulate innate and adaptive immune responses in TLR-7-dependent lupus. JCI Insight 3(23), e124729 (2018).

    Product Citations

    Jin, F., Li, Y., Li, T., et al. Inhibition of PADI2-mediated vimentin citrullination alleviates silica-induced pulmonary fibrosis in mice. Part. Fibre. Toxicol. (2026).

    Pasquero, S., Gugliesi, F., Griffante, G., et al. Novel antiviral activity of PAD inhibitors against human beta-coronaviruses HCoV-OC43 and SARS-CoV-2. Antiviral Res. 200, 105278 (2022).