An ACE inhibitor and active metabolite of moexipril
Related Products
Pro-drug Form(s)
21255Moexipril (hydrochloride)
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Moexiprilat

Item No. 38047

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3S)-2-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-3-isoquinolinecarboxylic acid
CAS Number
103775-14-0
Synonyms
  • RS 10029
Molecular Formula
C25H30N2O7
Formula Weight
470.5
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
C[C@H](N[C@H](C(O)=O)CCC1=CC=CC=C1)C(N2CC3=CC(OC)=C(OC)C=C3C[C@H]2C(O)=O)=O
InChi Code
InChI=1S/C25H30N2O7/c1-15(26-19(24(29)30)10-9-16-7-5-4-6-8-16)23(28)27-14-18-13-22(34-3)21(33-2)12-17(18)11-20(27)25(31)32/h4-8,12-13,15,19-20,26H,9-11,14H2,1-3H3,(H,29,30)(H,31,32)/t15-,19-,20-/m0/s1
InChi Key
CMPAGYDKASJORH-YSSFQJQWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $101

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    5 mg

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    10 mg

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    Product Description

    Moexiprilat is an inhibitor of angiotensin-converting enzyme (ACE; IC50 = 2.1 nM) and an active metabolite of the prodrug moexipril (Item No. 21255).1 It is formed from moexipril in vivo by side chain ester hydrolysis.2 Moexiprilat (10 nM) prevents the estrone- or angiotensin II-stimulated proliferation of primary neonatal rat cardiac fibroblasts.3 It reduces mean arterial blood pressure and increases the levels of atrial natriuretic peptide, a marker of hypertension, in ovariectomized mice when administered at a dose of 50 mg/kg per day.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Edling, O., Bao, G., Feelisch, M., et al. Moexipril, a new angiotensin-converting enzyme (ACE) inhibitor: Pharmacological characterization and comparison with enalapril. J. Pharmacol. Exp. Ther. 275(2), 854-863 (1995).

    2. Cameron, R.T., Coleman, R.G., Day, J.P., et al. Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4). Biochem. Pharmacol. 85(9), 1297-1305 (2013).

    3. Grohé, C., Kahlert, S., Löbber, K., et al. Angiotensin converting enzyme inhibition modulates cardiac fibroblast growth. J. Hypertens. 16(3), 377-384 (1998).

    4. van Eickels, M., Schreckenberg, R., Doevendans, P.A., et al. The influence of oestrogen-deficiency and ACE inhibition on the progression of myocardial hypertrophy in spontaneously hypertensive rats. Eur. J. Heart Fail. 7(7), 1079-1084 (2005).