Host: HEK293 cells • AA: 21-421 • Tag: C-terminal His • MW: 48.6 kDa
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Osteomodulin (human, recombinant)

Item No. 38054

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Keratan Sulfate Proteoglycan Osteomodulin
  • KSPG Osteomodulin
  • OMD
  • OSAD
  • Osteoadherin
Purity
≥95% as determined by SDS-PAGE
Endotoxin Testing
<1.0 EU/μg, determined by the LAL endotoxin assay
Source
Recombinant human C-terminal His-tagged osteomodulin expressed in HEK293 cells
Amino Acids
21-421
MW
48.6 kDa
Formulation (Request formulation change)
Lyophilized from sterile PBS, pH 7.4
UniProt Accession №
Q99983
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    50 µg

    $196

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    Product Description

    Osteomodulin (OMD), is a class II keratan sulfate small leucine-rich proteoglycan (SLRP) with roles in bone mineralization, cell adhesion, tooth formation, and the regulation of collagen fibrils.1,2 It is primarily expressed in mineralized tissues, including bones and teeth, but is also expressed in articular chondrocytes and fibrochondrocytes.1 OMD binds to bone morphogenetic protein 2 (BMP2), promoting SMAD signaling and osteogenesis. It also binds to type I collagen and induces morphology and size changes in collagen fibrils, indicating a role in the regulation of extracellular matrix components during bone formation.2 Increased plasma levels of OMD are associated with cardiac calcification in patients with chronic kidney disease (CKD).3 Serum levels of OMD are increased and positively correlated with plaque calcification in patients with carotid atherosclerosis. Serum levels of OMD are also decreased in patients with osteoarthritis.4 Cayman’s Osteomodulin (human, recombinant) protein consists of 412 amino acids, has a calculated molecular weight of 48.6 kDa, and a predicted N-terminus of Gln21 after signal peptide cleavage.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lin, W., Zhu, X., Gao, L., et al. Osteomodulin positively regulates osteogenesis through interaction with BMP2. Cell Death Dis. 12(2), 147 (2021).

    2. Tashima, T., Nagatoishi, S., Sagara, H., et al. Osteomodulin regulates diameter and alters shape of collagen fibrils. Biochem. Biophys. Res. Commun. 463(3), 292-296 (2015).

    3. Skenteris, N.T., Seime, T., Witasp, A., et al. Osteomodulin attenuates smooth muscle cell osteogenic transition in vascular calcification. Clin. Transl. Med. 12(2), e682 (2022).

    4. Sanchez, C., Mazzucchelli, G., Lambert, C., et al. Proteomic analysis of osteoblasts secretome provides new insights in mechanisms underlying osteoarthritis subchondral bone sclerosis. Osteoarthritis Cartilage 26(Suppl 1), S89 (2018).