Host: HEK293 cells • AA: 56-796 • Tag: N-terminal His • MW: 87.4 kDa
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

DPP-10 Extracellular Domain (human, recombinant)

Item No. 38055

Product Insert (PDF)
Technical Information
Synonyms
  • Dipeptidyl Peptidase 10
  • Dipeptidyl Peptidase IV-related Protein 3
  • Dipeptidyl Peptidase-like Protein 2
  • Dipeptidyl Peptidase Y
  • DPL2
  • DPRP-3
Purity
≥95% estimated by SDS-PAGE
Endotoxin Testing
<1.0 EU/µg determined by the LAL endotoxin assay
Source
Recombinant human N-terminal His-tagged DPP-10 expressed in HEK293 cells
Amino Acids
56-796
MW
87.4 kDa
Formulation (Request formulation change)
Lyophilized from sterile PBS, pH 7.4
UniProt Accession №
Q8N608-1
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µg

    $383

    Add
    Product Description

    Dipeptidyl peptidase 10 (DPP-10) is a catalytically inactive member of the prolyl oligopeptidase protein family.1,2,3 It is a type II transmembrane glycoprotein that lacks the serine residue of the catalytic triad essential to the serine protease activity observed in other DPPs.1 DPP-10 is expressed at high levels in the brain, pancreas, spinal cord, and adrenal glands, with lower levels in the placenta, liver, and trachea.2 Co-expression of DPP-10 with Kv4.2 voltage-gated potassium channels enhances channel currents and accelerates channel inactivation and recovery in Xenopus oocytes. Bronchoalveolar lavage fluid (BALF) levels of DPP-10 are increased in various mouse models of asthma, and serum levels of DPP-10 are increased in patients with NSAID-exacerbated respiratory disease (NERD).3 Cayman’s DPP-10 Extracellular Domain (human, recombinant) protein consists of 760 amino acids and has a calculated molecular mass of 87.4 kDa. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is approximately 90-110 kDa due to glycosylation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bezerra, G.A., Dobrovetsky, E., Seitova, A., et al. Structure of human dipeptidyl peptidase 10 (DPPY): A modulator of neuronal Kv4 channels. Sci. Rep. 5, 8769 (2015).

    2. Jerng, H.H., Qian, Y., and Pfaffinger, P.J. Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10). Biophys. J. 87(4), 2380-2396 (2004).

    3. Sim, S., Choi, Y., Lee, D.-H., et al. Contribution of dipeptidyl peptidase 10 to airway dysfunction in patients with NSAID-exacerbated respiratory disease. Clin. Exp. Allergy 52(1), 115-126 (2022).