Adrenomedullin (human, recombinant)

Adrenomedullin is a vasodilatory peptide hormone and member of the calcitonin peptide family encoded by ADM in humans, with roles in vasodilation, angiogenesis, inflammation, organ protection, and tissue repair.^1,2,3 ADM codes for a 185-amino acid precursor, preproadrenomedullin (preproAM), which is converted to proadrenomedullin (proAM) after cleavage of a signal peptide.³ proAM is then enzymatically processed to generate both adrenomedullin and proAM N-terminal 20 peptide (PAMP). Adrenomedullin is expressed in the adrenal medulla, heart, lung, and kidney as well as human umbilical vein endothelial cells (HUVECs) and in human glomerular epithelial and hematopoietic cell lines.¹ It is also expressed in pheochromocytomas, neuroendocrinal tumors of the adrenal gland. It is protective against mechanical ventilation-induced lung injury and sepsis, as well as liver and gut injury induced by ventilator-induced lung injury in a mouse model of pneumococcal pneumonia infection.⁴ Adrenomedullin increases survival and reduces chemotherapy-induced cardiotoxicity in mice.⁵ It also reduces hyperoxia-induced right ventricular hypertrophy and artery thickness in a rat model of bronchopulmonary dysplasia.¹ Cayman's Adrenomedullin (human, recombinant) protein is a disulfide-linked homodimer. The reduced monomer, composed of adrenomedullin (amino acids 95-146) fused to human IgG1 Fc at its N-terminus, consists of 340 amino acids and has a calculated molecular weight of 38 kDa.

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1. García-Ponce, A., Chánez Paredes, S., Castro Ochoa, K.F., et al. Regulation of endothelial and epithelial barrier functions by peptide hormones of the adrenomedullin family. Tissue Barriers 4(4), e1228439 (2016).

2. Lippton, H., Chang, J.K., Hao, Q., et al. Adrenomedullin dilates the pulmonary vascular bed in vivo. J. Appl. Physiol. 76(5), 2154-2156 (1994).

3. Martínez-Herrero, S., and Martínez, A. Adrenomedullin: Not just another gastrointestinal peptide. Biomolecules 12(2), 156 (2022).

4. Müller-Redetzky, H.C., Will, D., Hellwig, K., et al. Mechanical ventilation drives pneumococcal pneumonia into lung injury and sepsis in mice: Protection by adrenomedullin. Crit. Care 18(2), R73 (2014).

5. Yoshizawa, T., Takizawa, S., Shimada, S., et al. Effects of adrenomedullin on doxorubicin-induced cardiac damage in mice. Biol. Pharm. Bull. 39(5), 737-746 (2016).