Host: HEK293 cells • AA: 26-546 • Tag: N-terminal human IgG1 Fc • MW: 87.7 kDa
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Sema3A Sema Domain (human, recombinant; aa 26-546)

Item No. 38070

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Sema III
  • Semaphorin-3A
  • Semaphorin III
Purity
≥90% estimated by SDS-PAGE
Endotoxin Testing
<1.0 EU/µg, determined by the LAL endotoxin assay
Source
Recombinant N-terminal human IgG1 Fc-tagged Sema3A expressed in HEK293 cells
Amino Acids
26-546
MW
87.7 kDa
Formulation (Request formulation change)
Lyophilized from sterile PBS, pH 7.4
UniProt Accession №
Q14563
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    50 µg

    $218

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    Cayman Chemical
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    Product Description

    Semaphorin-3A (Sema3A) is a secreted glycoprotein and ligand of neuropilin-1 (NRP-1) and plexin A receptors.1,2 It is composed of a Sema domain, which mediates signaling and receptor specificity, a plexin-semaphorin-integrin (PSI) domain, an immunoglobulin (Ig) domain, and a C-terminal domain, which contains several basic residues that are important for NRP-1 binding. Sema3A is expressed in many tissues, including nervous, bone, and connective tissues and vascular endothelium, as well as some immune cells such as T cells and macrophages.1 It is involved in axonal guidance, bone remodeling, immunoregulation, and angiogenesis.1,2,3 Sema3A decreases the length and number of neurites in sensory and motor neurons in vitro and increases vascular permeability in mice.4,5 Heterozygous deletion of SEMA3A is associated with Kallmann syndrome, a disorder characterized by hypogonadotropic hypogonadism and an absent or decreased sense of smell.6 Cayman’s Sema3A Sema Domain (human, recombinant; aa 26-546) protein is a disulfide-linked homodimer. The reduced monomer, composed of Sema3A (amino acids 26-546) fused to human IgG1 Fc at its N-terminus, consists of 781 amino acids and has a calculated molecular weight of 87.7 kDa.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kiseleva, E.P., and Rutto, K.V. Semaphorin 3A in the immune system: Twenty years of study. Biochemistry (Mosc.) 87(7), 640-657 (2022).

    2. Li, Z., Hao, J., Duan, X., et al. The role of Semaphorin 3A in bone remodeling. Front. Cell. Neurosci. 11:40, (2017).

    3. He, Z., and Tessier-Lavigne, M. Neuropilin is a receptor for the axonal chemorepellent Semaphorin III. Cell 90(4), 739-751 (1997).

    4. Shen, M., Zhou, C., Tian, Y., et al. Effects of Semaphorin3A on the growth of sensory and motor neurons. Exp. Cell Res. 424(2), 113506 (2023).

    5. Acevedo, L.M., Barillas, S., Weis, S.M., et al. Semaphorin 3A suppresses VEGF-mediated angiogenesis yet acts as a vascular permeability factor. Blood 111(5), 2674-2680 (2008).

    6. Young, J., Metay, C., Bouligand, J., et al. SEMA3A deletion in a family with Kallmann syndrome validates the role of semaphorin 3A in human puberty and olfactory system development. Hum. Reprod. 27(5), 1460-1465 (2012).