Host: HEK293 cells • AA: 2-92 • Tag: N-terminal human IgG1 Fc • MW: 39 kDa
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

S100B (mouse, recombinant)

Item No. 38073

Product Insert (PDF)
Technical Information
Synonyms
  • S100β
  • S100 Calcium-binding Protein B
  • S100 Protein β Chain
  • S100 Protein Subunit β
Purity
≥80% estimated by SDS-PAGE
Endotoxin Testing
<1.0 EU/µg determined by the LAL endotoxin assay
Source
Recombinant N-terminal human IgG1 Fc-tagged mouse S100B expressed in HEK293 cells
Amino Acids
2-92
MW
39 kDa
Formulation (Request formulation change)
Lyophilized from sterile PBS, pH 7.4
UniProt Accession №
P50114
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    100 µg

    $328

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    S100 calcium-binding protein B (S100B) is a homodimeric protein, with each subunit containing two EF-hand calcium-binding domains.1 S100B is expressed primarily in astrocytes but also by neural progenitor cells, dendritic cells, some lymphocyte subpopulations, and maturing oligodendrocytes. S100B has intracellular roles in calcium homeostasis, cell proliferation, energy metabolism, cytoskeletal regulation, and motility. It is also released extracellularly in response to various forms of brain injury and acts as a damage-associated molecular pattern (DAMP) through its interaction with receptor for advanced glycation end products (RAGE).1,2,3,4 Peripheral blood levels of S100B are increased in patients with autism spectrum disorder, acute ischemic stroke, or neonatal brain injury.2,3,4 Cayman’s S100B (mouse, recombinant) protein is a disulfide-linked homodimer. The reduced monomer, composed of S100B (amino acids 2-92) fused to human IgG1 Fc at its N-terminus, consists of 351 amino acids, and has a calculated molecular weight of 39 kDa.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Angelopoulou, E., Paudel, Y.N., and Piperi, C. Emerging role of S100B protein implication in Parkinson’s disease pathogenesis. Cell. Mol. Life Sci. 78(4), 1445-1453 (2021).

    2. Zheng, Z., Zheng, P., and Zou, X. Peripheral blood S100B levels in autism spectrum disorder: A systematic review and meta-analysis. J. Autism Dev. Disord. 51(8), 2569-2577 (2021).

    3. Onatsu, J., Vanninen, R., Jäkälä, P., et al. Tau, S100B and NSE as blood biomarkers in acute cerebrovascular events. In Vivo 34(5), 2577-2586 (2020).

    4. Metallinou, D., Karampas, G., Nyktari, G., et al. S100B as a biomarker of brain injury in premature neonates. A prospective case - control longitudinal study. Clin. Chim. Acta 510, 781-786 (2020).