CXADR Rabbit Monoclonal Antibody (Clone 271)

Coxsackievirus and adenovirus receptor (CXADR) is a type I transmembrane glycoprotein with roles in forming cellular tight junctions, spermatogenesis, and viral infection.^1,2 Alternative splicing of CXADR generates three soluble isoforms, CXADR4/7, CXADR3/7, and CXADR2/7, and two membrane-bound isoforms, CXADR1 and CXADR2.¹ Membrane-bound isoforms of CXADR are composed of an extracellular domain containing two immunoglobulin-like (Ig-like) domains, a transmembrane domain, and an intracellular domain, which varies by isoform, is subject to post-translational modification, and contains a PDZ-binding motif, clathrin-adaptor protein recognition motif, and sorting motif. They function as major viral receptors for adenovirus species A and C-G and group B coxsackieviruses. Soluble isoforms of CXADR lack the transmembrane domain but also interact with both coxsackieviruses and adenoviruses. CXADR also functions as a cell junction component, interacting with various tight and adherens junction proteins to regulate barrier permeability, cell adhesion, and cell migration. Knockdown of CXADR in Sertoli cells compromises the blood-testis barrier, as well as induces germ cell apoptosis and premature loss of spermatids in mice.³ Endomyocardial CXADR expression is increased and positively correlated with IL-6 levels in patients with dilated cardiomyopathy.⁴ Cayman’s CXADR Rabbit Monoclonal Antibody (Clone 271) can be used for ELISA, flow cytometry (FC), immunocytochemistry (ICC), and immunofluorescence (IF) applications.

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1.  Molecular Mechanisms in Spermatogenesis. Advances in Experimental Medicine and Biology 1381, (2022).

2. Kobayashi, T., Matsugo, H., Maruyama, J., et al. Characterization of a novel species of adenovirus from Japanese microbat and role of CXADR as its entry factor. Sci. Rep. 9(1), 573 (2019).

3. Zhang, Y., and Lui, W.-Y. CXADR: From an essential structural component to a vital signaling mediator in spermatogenesis. Int. J. Mol. Sci. 24(2), 1288 (2023).

4. Gupalo, E.M., Buryachkovskaya, L.I., Chumachenko, P.V., et al. Implication of inflammation on Coxsackie virus and Adenovirus receptor expression on cardiomyocytes and the role of platelets in patients with dilated cardiomyopathy. Cardiovasc. Pathol. 60, 107452 (2022).