IFNAR1 Rabbit Monoclonal Antibody (Clone 110)

α/β receptor 1 (IFNAR1), also known as type I IFN receptor 1, is a class II helical cytokine receptor involved in the antiviral response.¹ It is composed of an extracellular domain, which contains four fibronectin type III subdomains, a transmembrane domain, and an intracellular domain, which contains a tyrosine kinase 2 (TYK2) phosphorylation site, and forms a heterodimer with IFNAR2.² It is ubiquitously expressed and binds to type I IFNs, including IFN-α, IFN-β, and IFN-ω, which, upon binding, together with IFNAR2 signals through JAK1, TYK2, and various STATs.³ Knockout of Ifnar1 sensitizes fibroblasts to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in vitro and has commonly been used as an immunosuppressive model to study viral infections in vivo.^4,5 SNPs in IFNAR1 are associated with increased risk of viral infections, lung cancer, multiple sclerosis, and cerebral malaria, as well as adverse reactions to vaccinations.¹ Cayman’s IFNAR1 Rabbit Monoclonal Antibody (Clone 110) can be used for immunocytochemistry (ICC) and immunofluorescence (IF) applications.

WARNING This product is not for human or veterinary use.

1. de Weerd, N.A., Vivian, J.P., Lim, S.S., et al. Structural integrity with functional plasticity: What type I IFN receptor polymorphisms reveal. J. Leukoc. Biol. 108(3), 909-924 (2020).

2. Borden, E.C., Sen, G.C., Uze, G., et al. Interferons at age 50: Past, current and future impact on biomedicine. Nat. Rev. Drug Discov. 6(12), 975-990 (2007).

3. de Weerd, N.A., and Nguyen, T. The interferons and their receptors - distribution and regulation. Immunol. Cell Biol. 90(5), 483-491 (2012).

4. Zhang, Q., Bastard, P., Liu, Z., et al. Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. Science 370(6515), eabd4570 (2020).

5. Marín-Lopez, A., Calvo-Pinilla, E., Moreno, S., et al. Modeling arboviral infection in mice lacking the interferon alpha/beta receptor. Viruses 11(1), 35 (2019).