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Interleukin-12Rβ2 Rabbit Monoclonal Antibody (Clone 093)

Item No. 38091

Product Insert (PDF)
Technical Information
Formal Name
For immunochemical detection of IL-12Rβ2
Synonyms
  • Interleukin-12R Subunit β2
  • Interleukin-12 Receptor Subunit β2
Immunogen
Recombinant mouse IL-12Rβ2
Clone Designation
093
Formulation (Request formulation change)
50 or 100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
0.2 μm filtered solution in PBS
Host
Rabbit
Isotype
IgG
Applications
ELISA
Cross Reactivity
(+) IL-12Rβ2
Species Reactivity
(+) Mouse
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    50 µl

    $179

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    100 µl

    $268

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    Product Description

    Interleukin-12Rβ2 (IL-12Rβ2) is a type I cytokine receptor that is involved in immunity.1 It is composed of an N-terminal immunoglobulin-like (Ig-like) domain, five fibronectin type III domains, which facilitate cytokine binding, a transmembrane domain, and an intracellular domain that contains tyrosine phosphorylation motifs. IL-12Rβ2 is selectively expressed in T helper 1 (Th1) over Th2 cells.2 IL-12Rβ2 forms a heterodimer with IL-12Rβ1 to form the IL-12R, and forms a homodimer or heterodimers with gp130 or IL-27Rα to form receptors for IL-35, which all primarily act through the JAK/STAT pathway.3 It is the functional receptor for IL-12, as Th2 cells that express IL-12Rβ1 are unresponsive to IL-12 stimulation. Knockout of Il12rb2 (Il12rb2-/-) prevents increases in serum IFN-γ levels in IL-12- or LPS-stimulated mice.4 Il12rb2-/- mice exhibit increased disease severity in a model of relapse-remitting experimental autoimmune encephalomyelitis.5 SNPs in IL12RB2 are associated with chronic obstructive pulmonary disease (COPD).6 Cayman’s Interleukin-12Rβ2 Rabbit Monoclonal Antibody (Clone 093) can be used for ELISA.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jones, L.L., and Vignali, D.A.A. Molecular interactions within the IL-6/IL-12 cytokine/receptor superfamily. Immunol. Res. 51(1), 5-14 (2011).

    2. Szabo, S.J., Dighe, A.S., Gubler, U., et al. Regulation of the interleukin (IL)-12R β2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 185(5), 817-824 (1997).

    3. Zhang, J., Zhang, Y., Wang, Q., et al. Interleukin-35 in immune-related diseases: Protection or destruction. Immunology 157(1), 13-20 (2019).

    4. Wu, C.-Y., Wang, X., Gadina, M., et al. IL-12 receptor β2 (IL-12Rβ2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites. J. Immunol. 165(11), 6221-6228 (2000).

    5. Xie, C., Ciric, B., Yu, S., et al. IL-12Rβ2 has a protective role in relapsing-remitting experimental autoimmune encephalomyelitis. J. Neuroimmunol. 291, 59-69 (2016).

    6. Fu, Y., Liu, L., and Wu, H. Role of genetic polymorphisms in IL12Rβ2 in chronic obstructive pulmonary disease. Int. J. Chron. Obstruct. Pulmon. Dis. 17, 1671-1683 (2022).