For immunochemical detection of IL-18
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Interleukin-18 Rabbit Monoclonal Antibody (Clone 011)

Item No. 38092

Product Insert (PDF)
Technical Information
Synonyms
  • IFN-γ-inducing Factor
  • IGIF
  • IL-18
  • IL-1γ
  • Interferon Gamma-inducing Factor
  • Interleukin-1γ
Immunogen
Recombinant human IL-18
Clone Designation
011
Formulation (Request formulation change)
50 or 100 µl, or 1 ml of protein A-affinity purified monoclonal antibody
Storage Buffer
0.2 μm filtered solution in PBS
Host
Rabbit
Isotype
IgG
Applications
ELISA, ELISA(CAP)
Cross Reactivity
(+) IL-18
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    50 µl

    $179

    Add

    100 µl

    $285

    Add

    1 ml

    $1,782

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

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    Product Description

    Interleukin-18 (IL-18) is a pro-inflammatory cytokine and member of the IL-1 cytokine family.1,2 It is synthesized as an inactive precursor peptide, pro-IL-18, in macrophages, dendritic cells, Kupffer cells, keratinocytes, chondrocytes, synovial fibroblasts, and osteoblasts, where it is cleaved by inflammasome-activated caspase-1 to form active IL-18.1,3 Active IL-18 is released from cells during pyroptosis, but inactive pro-IL-18 can also be secreted from dying cells and processed extracellularly by neutrophil proteinase 3, human chymase, and granzyme B.3 IL-18 binds to IL-18 receptors (IL-18Rs) on the surface of T helper 1 (Th1) and non-polarized T cells, natural killer (NK) cells, and NKT cells to induce intracellular signaling and IFN-γ production in response to viral, bacterial, or parasitic infection.2,3 It also binds to mast cells and basophils in conjunction with IL-3 to induce the production of IL-4 and IL-13, respectively. Inhibition of IL-18 with anti-IL-18 sera decreases survival in various mouse models of infection.3 Circulating levels of IL-18 are increased in patients with macrophage activation syndrome (MAS) or hemophagocytic lymphohistiocytosis (HLH).4 Cayman’s IL-18 Rabbit Monoclonal Antibody (Clone 011) can be used for ELISA and ELISA (CAP).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Arend, W.P., Palmer, G., and Gabay, C. IL-1, IL-18, and IL-33 families of cytokines. Immunol. Rev. 223, 20-38 (2008).

    2. Yasuda, K., Nakanishi, K., and Tsutsui, H. Interleukin-18 in health and disease. Int. J. Mol. Sci. 20(3), 649 (2019).

    3. Vecchié, A., Bonaventura, A., Toldo, S., et al. IL‐18 and infections: Is there a role for targeted therapies? J. Cell. Physiol. 236(3), 1638-1657 (2020).

    4. Grom, A.A., Horne, A., and De Benedetti, F. Macrophage activation syndrome in the era of biologic therapy. Nat. Rev. Rheumatol. 12(5), 259-268 (2016).