For immunochemical detection of TROP2
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

TROP2 Rabbit Monoclonal Antibody (Clone 046)

Item No. 38093

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Cell Surface Glycoprotein TROP-2
  • Membrane Component 1 Surface Marker 1
  • M1S1
  • TACSTD2
  • Trophoblast Cell Surface Antigen 2
  • Tumor-Associated Calcium Signal Transducer 2
Immunogen
Recombinant mouse Trop2
Clone Designation
046
Formulation (Request formulation change)
50 or 100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
0.2 μm filtered solution in PBS
Host
Rabbit
Isotype
IgG
Applications
IHC-P
Cross Reactivity
(+) Trop2
Species Reactivity
(+) Mouse
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    50 µl

    $179

    Add

    100 µl

    $285

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Trophoblast cell surface antigen 2 (TROP2), also known as tumor-associated calcium signal transducer 2 (TACSTD2), is a transmembrane glycoprotein and epithelial cell adhesion molecule (EpCAM) family member.1,2 It is composed of a signal peptide, an extracellular domain, which contains a cysteine-rich domain, thyroglobulin type-I domain, putative EGF-like domain, and cysteine-poor domain, a transmembrane domain, and a cytoplasmic tail, which contains a HIKE domain, PKC phosphorylation site, and a PtdIns-(4,5)-P2 (PIP2) binding site. Tacstd2 is expressed in trophoblasts, kidney, lung, ovary, and testis and localizes to the cell membrane and cytoplasm.3,4,1,5 TROP2 is involved in embryonic and fetal development, cell adhesion, migration, and proliferation and interacts with β-catenin, α5β1 integrin, and insulin-like growth factor 1 (IGF-1), among others.1 TROP2 is highly expressed in various cancer tissues, and overexpression of TACSTD2 increases metastasis in a colon cancer mouse xenograft model.1,6 Loss-of-function mutations in TACSTD2 result in gelatinous drop-like corneal dystrophy.5 Formulations containing an antibody-drug conjugate targeting TROP2 have been used in the treatment of triple-negative breast cancer (TNBC) and urothelial cancer. Cayman’s TROP2 Rabbit Monoclonal Antibody (Clone 046) can be used for immunohistochemistry (IHC; paraffin).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McDougall, A.R.A., Tolcos, M., Hooper, S.B., et al. Trop2: From development to disease. Dev. Dyn. 244(2), 99-109 (2014).

    2. Lenárt, S., Lenárt, P., Šmarda, J., et al. Trop2: Jack of all trades, master of none. Cancers (Basel) 12(11), 3328 (2020).

    3. Lipinski, M., Parks, D.R., Rouse, R.V., et al. Human trophoblast cell-surface antigens defined by monoclonal antibodies. Proc. Natl. Acad. Sci. USA 78(8), 5147-5150 (1981).

    4. El Sewedy, T., Fornaro, M., and Alberti, S. Cloning of the murine TROP2 gene: Conservation of a PIP2-binding sequence in the cytoplasmic domain of TROP-2. Int. J. Cancer 75(2), 324-330 (1998).

    5. Tsujikawa, M., Kurahashi, H., Tanaka, T., et al. Identification of the gene responsible for gelatinous drop-like corneal dystrophy. Nat. Genet. 21(4), 420-423 (1999).

    6. Guerra, E., Trerotola, M., Relli, V., et al. Trop-2 induces ADAM10-mediated cleavage of E-cadherin and drives EMT-less metastasis in colon cancer. Neoplasia 23(9), 898-911 (2021).