For immunochemical detection of ALDH1A1
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ALDH1A1 Monoclonal Antibody (Clone 5G9E6C9)

Item No. 38096

Product Insert (PDF)
Technical Information
Synonyms
  • Aldehyde Dehydrogenase 1A1
  • RALDH1
  • Retinaldehyde Dehydrogenase 1
Immunogen
Recombinant human ALDH1A1 protein
Clone Designation
5G9E6C9
Formulation (Request formulation change)
50, 100, or 200 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
0.2 μm filtered solution in PBS
Host
Mouse
Isotype
IgG1
Applications
ELISA, FC, ICC, IF, WB
Cross Reactivity
(+) ALDH1A1
Species Reactivity
(+) Human(-) E. coli
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    50 µl

    $179

    Add

    100 µl

    $268

    Add

    200 µl

    $446

    Add
    Cayman Chemical
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    Product Description

    Aldehyde dehydrogenase 1 (ALDH1) is an NADP+-dependent member of the aldehyde dehydrogenase superfamily that metabolizes exogenously produced aldehydes to alleviate aldehyde stress.1 ALDH1 is expressed as three isozymes, ALDH1A1, ALDH1A2, and ALDH1A3, of which, ALDH1A1 shares greater than 70% sequence homology with ALDH1A2 and ALDH1A3. ALDH1A1 is a cytosolic homotetramer, with each monomer composed of a catalytic domain, an NAD-binding domain, and an oligomerization domain that is widely expressed in brain, liver, kidneys, adipose tissue, retina, and lens. It catalyzes the oxidation of retinaldehyde to retinoic acid, a transcriptional regulator essential for normal cell growth and differentiation.1,2 Tumoral levels of ALDH1A1 are increased and associated with poor prognosis in patients with high clinical stages of nasopharyngeal carcinomas.2 Levels of ALDH1A1 are positively correlated with disease severity in postmortem brain tissue from patients with Alzheimer’s disease.3 ALDH1A1-positive nigrostriatal dopaminergic neurons (DANs) are decreased compared with the number of ALDH1A1-negative nigrostriatal DANs in postmortem brain tissue from patients with Parkinson’s disease.4 Cayman’s ALDH1A1 Monoclonal Antibody (Clone 5G9E6C9) can be used for ELISA, flow cytometry (FC), immunocytochemistry (ICC), immunofluorescence (IF), and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, B., Yang, K., Liang, D., et al. Discovery and development of selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors. Eur. J. Med. Chem. 209, 112940 (2021).

    2. Wang, H., Zhan, Y., Peng, S., et al. Targeting ALDH1A1 to induce necroptosis in nasopharyngeal carcinoma. J. Cancer 13(14), 3515-3525 (2022).

    3. Nikhil, K., Viccaro, K., and Shah, K. Multifaceted regulation of ALDH1A1 by Cdk5 in Alzheimer’s disease pathogenesis. Mol. Neurobiol. 56(2), 1366-1390 (2019).

    4. Carmichael, K., Evans, R.C., Lopez, E., et al. Function and regulation of ALDH1A1-positive nigrostriatal dopaminergic neurons in motor control and Parkinson’s disease. Front. Neural. Circuits 15, 644776 (2021).