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SLC3A2/CD98 Heavy Chain Rabbit Monoclonal Antibody (Clone 048)

Item No. 38102

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • CD98
  • CD98hc
  • 4F2HC
  • Solute Carrier Family 3 Member 2
Immunogen
Recombinant mouse SLC3A2
Clone Designation
048
Formulation (Request formulation change)
50 or 100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
0.2 μm filtered solution in PBS
Host
Rabbit
Isotype
IgG
Applications
IHC-P
Species Reactivity
(+) Mouse
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    50 µl

    $179

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    100 µl

    $268

    Add
    Cayman Chemical
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    Product Description

    Solute carrier family 3 member 2 (SLC3A2), also known as CD98 heavy chain (CD98hc), is a type II transmembrane glycoprotein.1,2,3,4 It is expressed in all cell types except platelets, with the highest levels in the gastrointestinal tract and renal tubules.2 SLC3A2 is composed of an extracellular domain, a single-pass transmembrane region, and a cytoplasmic domain. It heterodimerizes with various light chains, including the large neutral amino acids transporter small subunit 1 (LAT1) and LAT2, to form sodium-dependent transporters for neutral and positively charged amino acids and associates with β integrins to regulate integrin affinity and signaling, resulting in alterations in cell proliferation, adhesion, migration, and differentiation.1 SLC3A2 is associated with tumor growth, aggressiveness, and poor prognosis in patients with biliary tract cancer.5 It is also expressed on low-density neutrophils (LDNs), a subset of the neutrophil population that expands in patients with autoimmune disease, and is positively correlated with disease severity in patients with systemic lupus erythematosus (SLE).6 Cayman’s SLC3A2/CD98 Heavy Chain Rabbit Monoclonal Antibody (Clone 048) can be used for immunohistochemistry (IHC) (paraffin).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nguyen, H.T.T., and Merlin, D. Homeostatic and innate immune responses: Role of the transmembrane glycoprotein CD98. Cell Mol. Life Sci. 69(18), 3015-3026 (2012).

    2. Yan, Y., Vasudevan, S., Nguyen, H.T.T., et al. Intestinal epithelial CD98: An oligomeric and multifunctional protein. Biochim Biophys Acta. 1780(10), 1087-1092 (2008).

    3. Bulus, N., Feral, C., Pozzi, A., et al. CD98 increases renal epithelial cell proliferation by activating MAPKs. PLoS One. 7(6), e40026 (2012).

    4. Baumer, Y., McCurdy, S.P., Alcala, M., et al. CD98 regulates vascular smooth muscle cell proliferation in atherosclerosis. Atherosclerosis 256, 105-114 (2017).

    5. Kaira, K., Sunose, Y., Oriuchi, N., et al. CD98 is a promising prognostic biomarker in biliary tract cancer. Hepatobiliary Panceat.Dis.Int. 13(6), 654-657 (02/06/23).

    6. Martin, K.R., Day, J.A., Hansen, J.A., et al. CD98 defines a metabolically flexible, proinflammatory subset of low-density neutrophils in systemic lupus erythematosus. Clin. Transl. Med. 13(1), d1150 (2023).