For immunochemical detection of the MERS-CoV spike glycoprotein
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MERS-CoV Spike Glycoprotein Rabbit Monoclonal Antibody (Clone 723)

Item No. 38105

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein
Immunogen
Recombinant MERS-CoV spike glycoprotein
Clone Designation
723
Formulation (Request formulation change)
200 or 500 µg of protein A-affinity purified monoclonal antibody
Storage Buffer
0.2 μm filtered solution in PBS
Host
Rabbit
Isotype
IgG
Applications
MN
Cross Reactivity
(+) MERS-CoV spike glycoprotein(+) MERS-CoV spike glycoprotein S1(+) MERS-CoV spike glycoprotein RBD(-) MERS-CoV spike glycoprotein S2
Species Reactivity
(+) MERS-CoV
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    200 µg

    $220

    Add

    500 µg

    $330

    Add
    Cayman Chemical
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    Product Description

    Middle East respiratory syndrome coronavirus (MERS-CoV) is an enveloped positive-stranded RNA virus and a member of the Betacoronavirus genus and causative agent of MERS, an acute respiratory disease that often leads to pneumonia and renal failure.1,2 The MERS-CoV spike glycoprotein mediates viral attachment to host cells and virus-cell-mediated membrane fusion during infection.1 It is composed of an S1 subunit, which contains the receptor-binding domain (RBD) that binds to dipeptidyl peptidase-4 (DPP-4), and an S2 subunit containing heptad repeat regions 1 and 2, which are responsible for membrane fusion, as well as a transmembrane domain and a cytoplasmic tail. MERS-CoV is activated by cleavage of the spike glycoprotein into S1 and S2 subunits by various proteases, including TMPRSS2, cathepsin B, cathepsin L, and proprotein convertases, and blockage of this cleavage by protease inhibitors reduces MERS-CoV viral entry into target cells.1,3 Cayman’s MERS-CoV Spike Glycoprotein Rabbit Monoclonal Antibody (Clone 723) can be used for microneutralization (MN) assays.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Du, L., Yang, Y., Zhou, Y., et al. MERS-CoV spike protein: A key target for antivirals. Expert Opin. Ther. Targets 21(2), 131-143 (2017).

    2. Rabaan, A.A., Al-Ahmed, S.H., Haque, S., et al. SARS-CoV-2, SARS-CoV, and MERS-CoV: A comparative overview. Infez. Med. 28(2), 174-184 (2020).

    3. Zhou, N., Pan, T., Zhang, J., et al. Glycopeptide antibiotics potently inhibit cathepsin L in the late endosome/lysosome and block the entry of Ebola virus, Middle East respiratory syndrome coronavirus (MERS-CoV), and severe acute respiratory syndrome coronavirus (SARS-CoV). The Journal of Biological Chemisty 291(17), 9218-9232 (2020).