An active metabolite of RIPGBM
Related Products
Pro-drug Form(s)
27860RIPGBM
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Product Categories

Product Type

Biochemicals

Research Area

Cancer
Cancer Stem Cell Research
Cell Death
Apoptosis

cRIPGBM

Item No. 38115

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[(4-fluorophenyl)methyl]-2-methyl-4,9-dioxo-1-(phenylmethyl)-1H-naphth[2,3-d]imidazolium, monochloride
CAS Number
2361988-77-2
Molecular Formula
C26H20FN2O2 • Cl
Formula Weight
446.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly solubleDMSO: SolubleWater: Slightly soluble
SMILES
O=C1C2=C(N(CC3=CC=CC=C3)C(C)=[N+]2CC4=CC=C(F)C=C4)C(C5=CC=CC=C51)=O.[Cl-]
InChi Code
InChI=1S/C26H20FN2O2.ClH/c1-17-28(15-18-7-3-2-4-8-18)23-24(29(17)16-19-11-13-20(27)14-12-19)26(31)22-10-6-5-9-21(22)25(23)30;/h2-14H,15-16H2,1H3;1H/q+1;/p-1
InChi Key
IHNGETPFBJHWFE-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $81

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    10 mg

    $153

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    25 mg

    $362

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    Product Description

    cRIPGBM is an active metabolite of the anticancer prodrug RIPGBM (Item No. 27860).1 It is formed from RIPGBM selectively in GBM1 glioblastoma multiforme (GBM) cancer stem cells (CSCs) over primary human lung fibroblasts (HLFs). cRIPGBM induces apoptosis in GBM1 cells (EC50 = 68 nM). It binds to receptor-interacting serine/threonine kinase 2 (RIPK2) in a cell-free assay, as well as inhibits the interaction between RIPK2 and TGF-β-activated kinase 1 (TAK1) and promotes the interaction between RIPK2 and caspase-1 in GBM1 cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lucki, N.C., Villa, G.R., Vergani, N., et al. A cell type-selective apoptosis-inducing small molecule for the treatment of brain cancer. Proc. Natl. Acad. Sci. USA 116(13), 6435-6440 (2019).