An NSAID and active metabolite of fenbufen
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Pro-drug Form(s)
28851Fenbufen
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4-Biphenylacetic Acid

Item No. 38116

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[1,1′-biphenyl]-4-acetic acid
CAS Number
5728-52-9
Synonyms
  • p-Biphenylacetic Acid
  • Cl-83544
  • Felbinac
  • LY601017
  • NSC 16284
Molecular Formula
C14H12O2
Formula Weight
212.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly solubleMethanol: Slightly soluble
SMILES
OC(CC1=CC=C(C2=CC=CC=C2)C=C1)=O
InChi Code
InChI=1S/C14H12O2/c15-14(16)10-11-6-8-13(9-7-11)12-4-2-1-3-5-12/h1-9H,10H2,(H,15,16)
InChi Key
QRZAKQDHEVVFRX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 g

    $39

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    50 g

    $74

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    100 g

    $139

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    500 g

    $616

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    Product Description

    4-Biphenylacetic acid is a non-steroidal anti-inflammatory drug (NSAID) and an active metabolite of the prodrug fenbufen (Item No. 28851).1 It inhibits prostaglandin E2 (PGE2; Item No. 14010) synthesis in a cell-free assay (IC50 = 3.2 µM). In vivo, 4-biphenylacetic acid (2 mg/kg) suppresses UV-induced erythema in guinea pigs. 4-Biphenylacetic acid (16 mg/kg) reduces inflammation in a rat model of adjuvant-induced arthritis. It decreases phenylquinone-induced writhing in mice (ED50 = 9.9 mg/kg).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kerwar, S.S. Pharmacologic properties of fenbufen. Am. J. Med. 75(4B), 62-69 (1983).

    2. Brodgen, R.N., Heel, R.C., Speight, T.M., et al. Fenbufen: A review of its pharmacological properties and therapeutic use in rheumatic diseases and acute pain. Drugs 21(1), 1-22 (1981).