An ionizable cationic lipid
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1O14

Item No. 38150

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
15,19,28-tris(2-hydroxytetradecyl)-15,19,24,28-tetraazadotetracontane-13,30-diol
CAS Number
3117189-57-5
Molecular Formula
C80H166N4O5
Formula Weight
1264.2
Purity
≥95%
Formulation (Request formulation change)
A 25 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: 25 mg/ml
SMILES
OC(CCCCCCCCCCCC)CN(CC(O)CCCCCCCCCCCC)CCCN(CC(O)CCCCCCCCCCCC)CCCCNCCCN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC
InChi Code
InChI=1S/C80H166N4O5/c1-6-11-16-21-26-31-36-41-46-51-60-76(85)71-82(69-59-70-84(74-79(88)63-54-49-44-39-34-29-24-19-14-9-4)75-80(89)64-55-50-45-40-35-30-25-20-15-10-5)67-57-56-65-81-66-58-68-83(72-77(86)61-52-47-42-37-32-27-22-17-12-7-2)73-78(87)62-53-48-43-38-33-28-23-18-13-8-3/h76-81,85-89H,6-75H2,1-5H3
InChi Key
SOSDQKQICXEPKX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $112

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    10 mg

    $201

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    25 mg

    $445

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    Cayman Chemical
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    Product Description

    1O14 is an ionizable cationic lipid that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs).1 1O14-containing LNPs have been used for the delivery of IL-1β siRNA to induce gene silencing and hepatoprotective effects in a mouse model of acute liver injury induced by LPS and galactosamine (GalN).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, H., Ding, F., Zhu, Z., et al. Engineered ionizable lipid nanoparticles mediated efficient siRNA delivery to macrophages for anti-inflammatory treatment of acute liver injury. Int. J. Pharm. 631, 122489 (2023).