A pan-Glut inhibitor
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DRB18

Item No. 38217

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,5'-(((4-chloro-1,2-phenylene)bis(azanediyl))bis(methylene))bis(2-methylphenol)
CAS Number
2863686-81-9
Molecular Formula
C22H23ClN2O2
Formula Weight
382.9
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/ml
λmax
223 nm
SMILES
ClC1=CC(NCC2=CC(O)=C(C)C=C2)=C(NCC3=CC=C(C)C(O)=C3)C=C1
InChi Code
InChI=1S/C22H23ClN2O2/c1-14-3-5-16(9-21(14)26)12-24-19-8-7-18(23)11-20(19)25-13-17-6-4-15(2)22(27)10-17/h3-11,24-27H,12-13H2,1-2H3
InChi Key
WNTAQMQIZGJASL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $231

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    10 mg

    $369

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    25 mg

    $807

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    Cayman Chemical
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    Product Description

    DRB18 is a pan-inhibitor of glucose transporters (Gluts).1 It inhibits glucose uptake in HEK293 cells expressing Glut1, Glut2, Glut3, or Glut4 (IC50s = 2.6, 8.8, 4.5, and 0.9 µM, respectively) and in A549 and H1299 non-small cell lung cancer (NSCLC) cells (IC50s = 2.5 and 1.9 µM, respectively). DRB18 (10 µM) decreases the oxygen consumption rate (OCR) in a time-dependent manner, induces cell cycle arrest at the G1/S phase, and increases the levels of reactive oxygen species (ROS) in A549 cells. It decreases tumor volume and weight in an A549 mouse xenograft model when administered at a dose of 10 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shriwas, P., Roberts, D., Li, Y., et al. A small-molecule pan-class I glucose transporter inhibitor reduces cancer cell proliferation in vitro and tumor growth in vivo by targeting glucose-based metabolism. Cancer Metab. 9(1), 14 (2021).