An ionizable cationic lipid
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OC2-K3-E10

Item No. 38243

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,3'-((2-hydroxyethyl)azanediyl)bis(N-(3-(bis(2-hydroxydecyl)amino)propyl)propanamide)
CAS Number
2933216-12-5
Synonyms
  • I-28
Molecular Formula
C54H111N5O7
Formula Weight
942.5
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: 10 mg/ml
SMILES
OCCN(CCC(NCCCN(CC(O)CCCCCCCC)CC(O)CCCCCCCC)=O)CCC(NCCCN(CC(O)CCCCCCCC)CC(CCCCCCCC)O)=O
InChi Code
InChI=1S/C54H111N5O7/c1-5-9-13-17-21-25-31-49(61)45-58(46-50(62)32-26-22-18-14-10-6-2)39-29-37-55-53(65)35-41-57(43-44-60)42-36-54(66)56-38-30-40-59(47-51(63)33-27-23-19-15-11-7-3)48-52(64)34-28-24-20-16-12-8-4/h49-52,60-64H,5-48H2,1-4H3,(H,55,65)(H,56,66)
InChi Key
QUXHZASDVBKOSF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $83

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    5 mg

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    10 mg

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    50 mg

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    Cayman Chemical
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    Product Description

    OC2-K3-E10 is an ionizable cationic lipid.1 It has been used in the formation of lipid nanoparticles (LNPs) for the delivery of long intergenic noncoding RNA (lncRNA) in mice and for the delivery of CRISPR complementary single-guide RNA (sgRNA) and Cas9 mRNA for genome editing in transgenic mice.2,1 LNPs containing OC2-K3-E10 and encapsulating either gastric adenocarcinoma predictive lncRNA (GAPLINC) or diabetes-regulated anti-inflammatory RNA (DRAIR) lncRNA reduce LPS-induced increases in serum IL-1β or TNF-α and IL-6 levels, respectively, in mice.2 OC2-K3-E10-containing LNPs encapsulating macrophage inflammation-suppressing transcript lncRNA (MIST) modified with pseudouridine (ψ), but not with N1-methylpseudouridine (m1ψ) or 5-methylcytosine (m5C), reduce LPS-induced increases in TNF-α levels in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Khan, O.F., Tilstra, G., Manning, A.M., et al. Multi-motif dendrons and their supramolecular structures and uses thereof. (2023).

    2. Pang, J., Lau, Y.M.A., Mahbub, F., et al. Human and mouse long noncoding RNAs reengineered for exogenous delivery reduce LPS-induced inflammation in human macrophages and mice. Sci. Signal 19(928), eadx2924 (2026).