An antiviral ribonucleoside analog
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EIDD-2749

Item No. 38249

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4′-C-fluoro-uridine
CAS Number
1613589-24-4
Synonyms
  • 4’-FIU
  • 4’-Fluorouridine
Molecular Formula
C9H11FN2O6
Formula Weight
262.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 10 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
261 nm
SMILES
O[C@H]([C@@H]1O)[C@H](N(C=CC2=O)C(N2)=O)O[C@]1(F)CO
InChi Code
InChI=1S/C9H11FN2O6/c10-9(3-13)6(16)5(15)7(18-9)12-2-1-4(14)11-8(12)17/h1-2,5-7,13,15-16H,3H2,(H,11,14,17)/t5-,6+,7-,9-/m1/s1
InChi Key
RDCYLPRXPILMRP-JVZYCSMKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $44

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    10 mg

    $80

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    25 mg

    $176

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    50 mg

    $329

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    Cayman Chemical
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    Product Description

    EIDD-2749 is an antiviral ribonucleoside analog.1 Incorporation of EIDD-2749 into RSV or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA inhibits viral RNA-dependent RNA polymerase (RdRp) and induces transcriptional stalling in cell-free assays. It reduces viral yield in HEp-2 cells infected with clinical isolates of respiratory syncytial virus (RSV; EC50s = 0.61-1.2 µM). EIDD-2749 reduces apical virus shedding in RSV-infected isolated human airway epithelial (HAE) cells (EC50 = 55 nM). In vivo, EIDD-2749 (5 mg/kg) reduces lung virus load in a mouse model of RSV infection. It also reduces nasal viral titers in a ferret model of SARS-CoV-2 infection when administered at doses of 15 and 50 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sourimant, J., Lieber, C.M., Aggarwal, M., et al. 4'-Fluorouridine is an oral antiviral that blocks respiratory syncytial virus and SARS-CoV-2 replication. Science 375(6577), 161-167 (2022).