An ionizable cationic lipid
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YK-009

Item No. 38282

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-[[4-(decyloxy)-4-oxobutyl](2-hydroxyethyl)amino]-hexanoic acid, 2-octyldecyl ester
CAS Number
2761458-86-8
Molecular Formula
C40H79NO5
Formula Weight
654.1
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: 5 mg/ml
SMILES
OCCN(CCCCCC(OCC(CCCCCCCC)CCCCCCCC)=O)CCCC(OCCCCCCCCCC)=O
InChi Code
InChI=1S/C40H79NO5/c1-4-7-10-13-16-17-20-26-36-45-39(43)31-27-33-41(34-35-42)32-25-21-24-30-40(44)46-37-38(28-22-18-14-11-8-5-2)29-23-19-15-12-9-6-3/h38,42H,4-37H2,1-3H3
InChi Key
QXJDKBITLMHUSD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $82

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    5 mg

    $365

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    10 mg

    $647

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    Cayman Chemical
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    Product Description

    YK-009 is an ionizable cationic lipid (pKa = 6.512) that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs).1 Administration of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant mRNA in YK-009-containing LNPs induces the production of IgG that binds to the SARS-CoV-2 receptor-binding domain (RBD) in mice, with a boost in IgG titers 10 days after a second dose.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Long, J., Yu, C., Zhang, H., et al. Novel ionizable lipid nanoparticles for SARS-CoV-2 omicron mRNA delivery. Adv. Healthc. Mater. 12(13), 2202590 (2023).