A σ1 receptor ligand and dopaminergic stabilizer
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Pridopidine

Item No. 38302

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[3-(methylsulfonyl)phenyl]-1-propyl-piperidine
CAS Number
346688-38-8
Synonyms
  • ACR16
  • ASP2314
  • FR310826
Molecular Formula
C15H23NO2S
Formula Weight
281.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: SolubleMethanol: Soluble
SMILES
O=S(C1=CC(C2CCN(CC2)CCC)=CC=C1)(C)=O
InChi Code
InChI=1S/C15H23NO2S/c1-3-9-16-10-7-13(8-11-16)14-5-4-6-15(12-14)19(2,17)18/h4-6,12-13H,3,7-11H2,1-2H3
InChi Key
YGKUEOZJFIXDGI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $79

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    10 mg

    $148

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    25 mg

    $252

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    50 mg

    $466

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    Product Description

    Pridopidine is a ligand of sigma non-opioid intracellular receptor 1 (σ1 receptor) and a dopaminergic stabilizer.1,2 It binds to the σ1 receptor and dopamine D2 receptor in the high-affinity state (Kis = 81.3 and 7,521 nM, respectively). Pridopidine (100 µmol/kg) increases striatal 3,4-dihydroxyphenylacetic acid (DOPAC) levels and locomotor activity, as well as inhibits amphetamine-induced locomotor activity, in rats.2 It improves motor function and reduces striatal mutant huntingtin (mHtt) aggregates in the R6/2 mouse model of Huntington’s disease when administered at doses of 5 or 6 mg/kg.3 Pridopidine (30 mg/kg) prevents muscle atrophy and the loss of innervated neuromuscular junctions in the SOD1-G93A mouse model of amyotrophic lateral sclerosis (ALS).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sahlholm, K., Århem, P., Fuxe, K., et al. The dopamine stabilizers ACR16 and (–)-OSU6162 display nanomolar affinities at the σ-1 receptor. Mol. Psychiatry 18(1), 12-14 (2013).

    2. Pettersson, F., Pontén, H., Waters, N., et al. Synthesis and evaluation of a set of 4-phenylpiperidines and 4-phenylpiperazines as D2 receptor ligands and the discovery of the dopaminergic stabilizer 4-[3-(methylsulfonyl)phenyl]-1-propylpiperidine (huntexil, pridopidine, ACR16). J. Med. Chem. 53(6), 2510-2520 (2013).

    3. Squitieri, F., Di Pardo, A., Favellato, M., et al. Pridopidine, a dopamine stabilizer, improves motor performance and shows neuroprotective effects in Huntington disease R6/2 mouse model. J. Cell. Mol. Med. 19(11), 2540-2548 (2015).

    4. Ionescu, A., Gradus, T., Altman, T., et al. Targeting the sigma-1 receptor via pridopidine ameliorates central features of ALS pathology in a SOD1G93A model. Cell Death Dis. 10(3), 210 (2019).