An ionizable cationic trialkyl lipid
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Lipid CL1

Item No. 38320

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(dimethylamino)-pentanoic acid, (6Z)-1,2-di-(4Z)-4-decen-1-yl-6-dodecen-1-yl ester
CAS Number
1450888-71-7
Synonyms
  • Lipid 10
Molecular Formula
C39H73NO2
Formula Weight
588.0
Purity
≥95%
Formulation (Request formulation change)
A 25 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: 10 mg/ml
SMILES
O=C(CCCCN(C)C)OC(CCC/C=C\CCCCC)C(CCC/C=C\CCCCC)CCC/C=C\CCCCC
InChi Code
InChI=1S/C39H73NO2/c1-6-9-12-15-18-21-24-27-32-37(33-28-25-22-19-16-13-10-7-2)38(34-29-26-23-20-17-14-11-8-3)42-39(41)35-30-31-36-40(4)5/h18-23,37-38H,6-17,24-36H2,1-5H3/b21-18-,22-19-,23-20-
InChi Key
ARJCMRWHZPDQJG-ASSJVFBPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $196

    Add

    10 mg

    $314

    Add

    25 mg

    $686

    Add

    50 mg

    $1,077

    Add
    Cayman Chemical
    Ionizable Lipids – Your Path from R&D to GMP

    Seamlessly bridge your LNP discovery journey from RUO to bulk GLP-tox and GMP excipient-grade material.

    Explore CGMP Lipid Services
    Product Description

    Lipid CL1 is an ionizable cationic trialkyl lipid (pKa = 6.3) that has been used in the formation of lipid nanoparticles (LNPs) for delivering mRNA in vivo.1,2 LNPs containing lipid CL1 and encapsulating mRNA encoding human erythropoietin (EPO) increase blood EPO protein levels in mice.2 LNPs containing lipid CL1 and encapsulating mRNA encoding a reporter protein increase reporter expression in the liver to a greater extent than LNPs containing the ionizable lipids DLin-DMA (Item No. 36701), KC2 (DLin-KC2-DMA; Item No. 34363), MC3 (DLin-MC3-DMA; Item No. 34364), or LP-01 (Item No. 37278) in mice.1 LNPs containing lipid CL1 and encapsulating mRNA encoding influenza A hemagglutinin (HA) increase anti-HA IgG antibody titers to a greater extent than LNPs containing the ionizable cationic lipid SM-102 (Item No. 33474) in a mouse model of HA vaccination.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lam, K., Leung, A., Martin, A., et al. Unsaturated, trialkyl ionizable lipids are versatile lipid-nanoparticle components for therapeutic and vaccine applications. Adv. Mater. 35(15), e2209624 (2023).

    2. Hayes, J., Judge, A., Lam, K.M., et al. Lipid nanoparticles. (2022).