A TRPML1 agonist
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ML-SA5

Item No. 38326

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N4-[3-chloro-2-(1-piperidinyl)phenyl]-N1,N1-dimethyl-1,4-benzenedisulfonamide
CAS Number
2418670-70-7
Synonyms
  • Mucolipin Synthetic Agonist 5
Molecular Formula
C19H24ClN3O4S2
Formula Weight
458.0
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
O=S(NC1=C(N2CCCCC2)C(Cl)=CC=C1)(C3=CC=C(S(=O)(N(C)C)=O)C=C3)=O
InChi Code
InChI=1S/C19H24ClN3O4S2/c1-22(2)29(26,27)16-11-9-15(10-12-16)28(24,25)21-18-8-6-7-17(20)19(18)23-13-4-3-5-14-23/h6-12,21H,3-5,13-14H2,1-2H3
InChi Key
YPPWKTIVYUTTEH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $33

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    5 mg

    $139

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    10 mg

    $261

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    25 mg

    $611

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    Cayman Chemical
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    Product Description

    ML-SA5 is an agonist of transient receptor potential mucolipin 1 (TRPML1).1 It activates whole-endolysosome TRPML1-mediated current (IML1) in isolated vacuoles that were enlarged by vacuolin-1 (Item No. 20425) (EC50 = 333 nM). ML-SA5 (3 µM) is cytotoxic to MeWo and M12 melanoma cells but not normal melanocytes. It induces gastric acid secretion in isolated stomach from wild-type but not TRPML1-/- mice.2 ML-SA5 (2 and 5 mg/kg) decreases the necrotic area and percentage of centrally nucleated fibers in the dystrophin-deficient mdx mouse model of Duchenne muscular dystrophy.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Du, W., Gu, M., Hu, M., et al. Lysosomal Zn2+ release triggers rapid, mitochondria-mediated, non-apoptotic cell death in metastatic melanoma. Cell Rep. 37(3), 109848 (2021).

    2. Sahoo, N., Gu, M., Zhang, X., et al. Gastric acid secretion from parietal cells is mediated by a Ca2+ efflux channel in the tubulovesicle. Dev. Cell 41(3), 262-273 (2017).

    3. Yu, L., Zhang, X., Yang, Y., et al. Small-molecule activation of lysosomal TRP channels ameliorates Duchenne muscular dystrophy in mouse models. Sci. Adv. 6(6), eaaz2736 (2020).