An inhibitor of the survivin-Hsp90 interaction
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Shepherdin (trifluoroacetate salt)

Item No. 38327

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-lysyl-L-histidyl-L-seryl-L-serylglycyl-L-cysteinyl-L-alanyl-L-phenylalanyl-L-leucine, trifluoroacetate salt
Synonyms
  • Lys-His-Ser-Ser-Gly-Cys-Ala-Phe-Leu-OH
  • Survivin (79-87)
Molecular Formula
C41H64N12O12S • XCF3COOH
Formula Weight
949.1
Purity
≥90%
Formulation (Request formulation change)
A solid
Peptide Sequence
KHSSGCAFL-OH
Solubility(Learn about Variance in Solubility)
Methanol: Soluble
SMILES
O=C(N[C@H](C(O)=O)CC(C)C)[C@@H](NC([C@H](C)NC([C@H](CS)NC(CNC([C@H](CO)NC([C@H](CO)NC([C@@H](NC([C@@H](N)CCCCN)=O)CC1=CN=CN1)=O)=O)=O)=O)=O)=O)CC2=CC=CC=C2.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C41H64N12O12S.C2HF3O2/c1-22(2)13-29(41(64)65)51-37(60)27(14-24-9-5-4-6-10-24)49-34(57)23(3)47-40(63)32(20-66)48-33(56)17-45-36(59)30(18-54)52-39(62)31(19-55)53-38(61)28(15-25-16-44-21-46-25)50-35(58)26(43)11-7-8-12-42;3-2(4,5)1(6)7/h4-6,9-10,16,21-23,26-32,54-55,66H,7-8,11-15,17-20,42-43H2,1-3H3,(H,44,46)(H,45,59)(H,47,63)(H,48,56)(H,49,57)(H,50,58)(H,51,60)(H,52,62)(H,53,61)(H,64,65);(H,6,7)/t23-,26-,27-,28-,29-,30-,31-,32-;/m0./s1
InChi Key
ISRJQWVUEJCODH-BNRNJGPNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $29

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    5 mg

    $80

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    10 mg

    $129

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    25 mg

    $286

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    Cayman Chemical
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    Product Description

    Shepherdin is a synthetic peptide that corresponds to amino acids 79-87 of human survivin and an inhibitor of the protein-protein interaction between survivin and heat shock protein 90 (Hsp90).1 It binds to the N-terminal domain of Hsp90 in a concentration-dependent manner and inhibits the interaction between recombinant human survivin and Hsp90 in isolated human reticulocyte extracts when used at a concentration of 150 µM. Peptide conjugates of shepherdin with the cell-permeable peptides penetratin (Item No. 36878) or HIV Tat sequence have anticancer activity in vitro and in vivo.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Plescia, J., Salz, W., Xia, F., et al. Rational design of shepherdin, a novel anticancer agent. Cancer Cell 7(5), 457-468 (2005).