A STING agonist
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STING Agonist 12L

Item No. 38344

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-([3,4'-bipyridazine]-6-carboxamido)-4-ethynyl-5-fluorobenzoic acid
CAS Number
2913152-30-2
Synonyms
  • Stimulator of Interferon Genes Agonist 12L
Molecular Formula
C18H10FN5O3
Formula Weight
363.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 5 mg/mlPBS (pH 7.2): 2 mg/ml
SMILES
O=C(O)C1=CC(F)=C(C#C)C=C1NC(C2=NN=C(C3=CC=NN=C3)C=C2)=O
InChi Code
InChI=1S/C18H10FN5O3/c1-2-10-7-16(12(18(26)27)8-13(10)19)22-17(25)15-4-3-14(23-24-15)11-5-6-20-21-9-11/h1,3-9H,(H,22,25)(H,26,27)
InChi Key
KEGLNBCLJXFLRV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Product Description

    STING agonist 12L is an agonist of stimulator of interferon genes (STING).1 It binds to wild-type STING (IC50 = 1.15 µM), as well as the STING R232, AQ, and Q variants (IC50s = 1.06, 0.61, and 1.12 µM, respectively) and induces reporter gene expression in THP-1 and RAW 264.7 cells (EC50s = 0.38 and 12.94 µM, respectively). STING agonist 12L (5 µM) induces IFNB1, CXCL10, and IL6 mRNA expression in THP-1 cells. In vivo, STING agonist 12L (10 mg/kg) increases plasma IFN-β levels and reduces tumor volume and the number of lung metastases in a B16/F10 murine melanoma model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shan, B., Hou, H., Zhang, K., et al. Design, synthesis, and biological evaluation of bipyridazine derivatives as stimulator of interferon genes (STING) receptor agonists. J. Med. Chem. 66(5), 3327-3347 (2023).