A STING agonist
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STING Agonist 23

Item No. 38345

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N'-(pentane-1,5-diyl)bis(5-nitrofuran-2-carboxamide)
CAS Number
2951078-67-2
Synonyms
  • Stimulator of Interferon Genes Agonist 23
Molecular Formula
C15H16N4O8
Formula Weight
380.3
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 16 mg/mlDMSO: 14 mg/ml
λmax
215, 308 nm
SMILES
O=C(NCCCCCNC(C1=CC=C([N+]([O-])=O)O1)=O)C2=CC=C([N+]([O-])=O)O2
InChi Code
InChI=1S/C15H16N4O8/c20-14(10-4-6-12(26-10)18(22)23)16-8-2-1-3-9-17-15(21)11-5-7-13(27-11)19(24)25/h4-7H,1-3,8-9H2,(H,16,20)(H,17,21)
InChi Key
FWFARJQDNUCDBL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Cayman Chemical
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    Product Description

    STING agonist 23 is an agonist of stimulator of interferon genes (STING).1 It increases the phosphorylation of TANK-binding kinase 1 (TBK1) in wild-type, but not STING-deficient, HT-1080 cells when used at a concentration of 20 µM. STING agonist 23 induces dimerization of STING in THP-1 cells and mouse bone marrow-derived macrophages (BMDMs) in a concentration-dependent manner. It inhibits the replication of herpes simplex virus (HSV), rhesus rotavirus (RRV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro (EC50s = 6.15, 6.8, and 10.71 µM, respectively). In vivo, STING agonist 23 increases serum levels of IFN-β and TNF-α in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zang, R., Xue, L., Zhang, M., et al. Design and syntheses of a bimolecular STING agonist based on the covalent STING antagonist. Eur. J. Med. Chem. 250, 115184 (2023).