A diterpenoid with anticancer and neuroprotective activities
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Isomer(s)
40078Erinacine B
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Erinacine A

Item No. 38352

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3,3aR,4,5,5aR,6S,7-octahydro-3a,5a-dimethyl-1-(1-methylethyl)-6-(β-D-xylopyranosyloxy)-cyclohept[e]indene-8-carboxaldehyde
CAS Number
156101-08-5
Synonyms
  • Erinacin A
  • (+)-Erinacin A
Molecular Formula
C25H36O6
Formula Weight
432.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleMethanol: Soluble
SMILES
C[C@](CC1)(CC2)C(C([C@@]1([C@H](C3)O[C@H](OC[C@H]4O)[C@@H]([C@H]4O)O)C)=CC=C3C=O)=C2C(C)C
InChi Code
InChI=1S/C25H36O6/c1-14(2)16-7-8-24(3)9-10-25(4)17(20(16)24)6-5-15(12-26)11-19(25)31-23-22(29)21(28)18(27)13-30-23/h5-6,12,14,18-19,21-23,27-29H,7-11,13H2,1-4H3/t18-,19+,21+,22-,23+,24-,25-/m1/s1
InChi Key
LPPCHLAEVDUIIW-NLLUTMDRSA-N
Origin
Natural/Lion's mane mushroom powder
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

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    Product Description

    Erinacine A is a diterpenoid that has been found in H. erinaceum and has anticancer and neuroprotective activities.1,2,3,4 It decreases the viability of, and induces cell cycle arrest at the G1 phase and production of reactive oxygen species (ROS) in, DLD-1 colorectal cancer cells when used at a concentration of 10 µM.2 Erinacine A (1 mM) increases the production of nerve growth factor (NGF) in mouse astroglial cells.1 In vivo, erinacine A (1 mg/kg, i.p.) increases the time spent on the rod in a rotarod test in a mouse model of MPTP-induced Parkinson’s disease.3 Oral administration of erinacine A (4 mg/kg) decreases infarct volume in a mouse model of ischemic brain injury induced by transient right common carotid artery occlusion.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kawagishi, H., Shimada, A., Shirai, R., et al. Erinacines A, B and C, strong stimulators of nerve growth factor (NGF)-synthesis from the mycelia of Hericium erinaceum. Tetrahedron Lett. 35(10), 1569-1572 (1994).

    2. Lu, C.-C., Huang, W.-S., Lee, K.-F., et al. Inhibitory effect of erinacines A on the growth of DLD-1 colorectal cancer cells is induced by generation of reactive oxygen species and activation of p70S6K and p21. J. Funct. Foods 21, 474-484 (2016).

    3. Lee, K.-F., Tung, S.-Y., Teng, C.-C., et al. Post-treatment with erinacine A, a derived diterpenoid of H. erinaceus, attenuates neurotoxicity in MPTP model of Parkinson’s disease. Antioxidants (Basel) 9(2), 137 (2020).

    4. Hsu, P.-C., Lan, Y.-J., Chen, C.-C., et al. Erinacine A attenuates glutamate transporter 1 downregulation and protects against ischemic brain injury. Life Sci. 306:120833, (2022).