A TRPM2 agonist
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2'-Deoxyadenosine-5'-O-diphosphoribose (sodium salt)

Item No. 38356

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2′-deoxy-adenosine 5′-(trihydrogen diphosphate), P′→5-ester with D-ribose, disodium salt
Synonyms
  • 2′-deoxy ADPR
Molecular Formula
C15H21N5O13P2 • 2Na
Formula Weight
587.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
NC1=C(N=CN2[C@@H]3O[C@H](COP(OP(OC[C@@H](O)[C@@H](O)[C@@H](O)C=O)([O-])=O)([O-])=O)[C@@H](O)C3)C2=NC=N1.[Na+].[Na+]
InChi Code
InChI=1S/C15H23N5O13P2.2Na/c16-14-12-15(18-5-17-14)20(6-19-12)11-1-7(22)10(32-11)4-31-35(28,29)33-34(26,27)30-3-9(24)13(25)8(23)2-21;;/h2,5-11,13,22-25H,1,3-4H2,(H,26,27)(H,28,29)(H2,16,17,18);;/q;2*+1/p-2/t7-,8-,9+,10+,11+,13-;;/m0../s1
InChi Key
OWBODBSRHMMQRQ-AGZKKVMKSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $478

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    Product Description

    2'-Deoxyadenosine-5'-O-diphosphoribose is a transient receptor potential melastatin 2 (TRPM2) agonist.1 It increases calcium-induced currents in an inside-out patch clamp assay using HEK293 cells expressing human TRPM2 when used at a concentration of 30 µM. 2'-Deoxyadenosine-5'-O-diphosphoribose has been found in Jurkat cells. It is also a substrate of nucleotide triphosphate diphosphatase 9 (NUDT9), a mitochondrial enzyme involved in hydrolyzing pyrophosphates.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fliegert, R., Bauche, A., Pérez, A.-M.W., et al. 2'-Deoxyadenosine 5'-diphosphoribose is an endogenous TRPM2 superagonist. Nat. Chem. Biol. 13(9), 1036-1044 (2017).

    2. Gattkowski, E., Rutherford, T.J., Möckl, F., et al. Analysis of ligand binding and resulting conformational changes in pyrophosphatase NUDT9. FEBS J. 288(23), 6769-6782 (2021).