An HMG-CoA reductase inhibitor
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Adenosine-5'-O-diphosphoribose phosphate (sodium salt)

Item No. 38358

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
adenosine 5′-(trihydrogen diphosphate), 2′-(dihydrogen phosphate), P′→5-ester with D-ribose, tetrasodium salt
Synonyms
  • Adenosine 2’-monophospho-5’-diphosphoribose
  • ADP-ribose Phosphate
  • P-ADP-Rib
Molecular Formula
C15H20N5O17P3 • 4Na
Formula Weight
727.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O=P(OC[C@@H](O)[C@@H](O)[C@@H](O)C=O)([O-])OP(OC[C@H]1O[C@@H](N2C=NC3=C(N)N=CN=C32)[C@H](OP([O-])([O-])=O)[C@@H]1O)([O-])=O.[Na+].[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C15H24N5O17P3.4Na/c16-13-9-14(18-4-17-13)20(5-19-9)15-12(36-38(26,27)28)11(25)8(35-15)3-34-40(31,32)37-39(29,30)33-2-7(23)10(24)6(22)1-21;;;;/h1,4-8,10-12,15,22-25H,2-3H2,(H,29,30)(H,31,32)(H2,16,17,18)(H2,26,27,28);;;;/q;4*+1/p-4/t6-,7+,8+,10-,11+,12+,15+;;;;/m0..../s1
InChi Key
ZPVQESFXMKOSGB-ACKYLPNWSA-J
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    3.2 mg

    $224

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    Product Description

    Adenosine-5’-O-diphosphoribose phosphate (ADP-ribose phosphate) is an inhibitor of HMG-CoA reductase and a derivative of the nucleotide sugar ADP-ribose that is phosphorylated at the 2’ position.1 It selectively inhibits rat liver microsomal HMG-CoA reductase in its non-allosteric form with apparent Ki values of 53 and 550 µM at high and low thiol concentrations, respectively, which are associated with its non-allosteric and allosteric forms.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Roitelman, J., and Shechter, I. Allosteric and non-allosteric forms of rat liver 3-hydroxy-3-methylglutaryl coenzyme A reductase: Differential inhibition of activity by adenosine 2'-monophospho-5'-diphosphoribose. J. Lipid Res. 27(8), 828-835 (1986).