A reverse transcriptase inhibitor
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2',3'-Dideoxyguanosine-5'-O-triphosphate (sodium salt)

Item No. 38375

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2′,3′-dideoxy-guanosine 5′-(tetrahydrogen triphosphate), tetrasodium salt
Synonyms
  • ddGTP
Molecular Formula
C10H12N5O12P3 • 4Na
Formula Weight
579.1
Purity
≥95%
Formulation (Request formulation change)
A solution in water
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
[O-]P(OP(OC[C@@H]1CC[C@H](N2C(NC(N)=NC3=O)=C3N=C2)O1)([O-])=O)(OP([O-])([O-])=O)=O.[Na+].[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C10H16N5O12P3.4Na/c11-10-13-8-7(9(16)14-10)12-4-15(8)6-2-1-5(25-6)3-24-29(20,21)27-30(22,23)26-28(17,18)19;;;;/h4-6H,1-3H2,(H,20,21)(H,22,23)(H2,17,18,19)(H3,11,13,14,16);;;;/q;4*+1/p-4/t5-,6+;;;;/m0..../s1
InChi Key
AIFBYZLQROBIRU-YPNYOHIOSA-J
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    2.5 mg

    $447

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    Product Description

    2',3'-Dideoxyguanosine-5'-O-triphosphate (ddGTP) is a reverse transcriptase inhibitor (Kis = 13 and 6.7 nM for the visna virus and HIV-1 enzymes, respectively).1,2 ddGTP has been used in the synthesis of oligonucleotides containing a terminal ddG that are resistant to cleavage by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exonuclease.3 ddGTP has also been used to terminate chain extension produced by the Taq polymerase in PCR assays.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Frank, K.B., McKernan, P.A., Smith, R.A., et al. Visna virus as an in vitro model for human immunodeficiency virus and inhibition by ribavirin, phosphonoformate, and 2',3'-dideoxynucleosides. Antimicrob. Agents Chemother. 31(9), 1369-1374 (1987).

    2. Ueno, T., Shirasaka, T., and Mitsuya, H. Enzymatic characterization of human immunodeficiency virus type 1 reverse transcriptase resistant to multiple 2',3'-dideoxynucleoside 5'-triphosphates. The Journal of Biological Chemisty 270(40), 23605-23611 (1995).

    3. Wang, X., Tao, C., Morozova, I., et al. Identifying structural features of nucleotide analogues to overcome SARS-CoV-2 exonuclease activity. Viruses 14(7), 1413 (2022).

    4. Li, Y., Mitaxov, V., and Waksman, G. Structure-based design of Taq DNA polymerases with improved properties of dideoxynucleotide incorporation. Proc. Natl. Acad. Sci. USA 96(17), 9491-9496 (1999).