A reverse transcriptase inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

2',3'-Dideoxythymidine-5'-O-triphosphate (sodium salt)

Item No. 38376

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
((2S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl triphosphate
Synonyms
  • ddTTP
Molecular Formula
C10H13N2O13P3 • 4Na
Formula Weight
554.1
Purity
≥95%
Formulation (Request formulation change)
A 10 mM solution in water
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O=C(N(C=C1C)[C@H]2CC[C@@H](COP([O-])(OP(OP([O-])([O-])=O)([O-])=O)=O)O2)NC1=O.[Na+].[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C10H17N2O13P3.4Na/c1-6-4-12(10(14)11-9(6)13)8-3-2-7(23-8)5-22-27(18,19)25-28(20,21)24-26(15,16)17;;;;/h4,7-8H,2-3,5H2,1H3,(H,18,19)(H,20,21)(H,11,13,14)(H2,15,16,17);;;;/q;4*+1/p-4/t7-,8+;;;;/m0..../s1
InChi Key
OKYHUQUPPJASGU-JWQBCWJNSA-J
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    2.3 mg

    $186

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    2',3'-Dideoxythymidine-5'-O-triphosphate (ddTTP) is a reverse transcriptase inhibitor (Kis = 40 and 25 nM for the visna virus and HIV-1 enzymes, respectively).1,2 It also inhibits DNA polymerase γ (Ki = 400 nM for the bovine enzyme).3 ddTTP has been used to terminate chain extension produced by the Taq polymerase in PCR assays.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Frank, K.B., McKernan, P.A., Smith, R.A., et al. Visna virus as an in vitro model for human immunodeficiency virus and inhibition by ribavirin, phosphonoformate, and 2',3'-dideoxynucleosides. Antimicrob. Agents Chemother. 31(9), 1369-1374 (1987).

    2. Ueno, T., Shirasaka, T., and Mitsuya, H. Enzymatic characterization of human immunodeficiency virus type 1 reverse transcriptase resistant to multiple 2',3'-dideoxynucleoside 5'-triphosphates. The Journal of Biological Chemisty 270(40), 23605-23611 (1995).

    3. Izuta, S., Saneyoshi, T., Sakurai, T., et al. The 5′-triphosphates of 3′-azido-3′-deoxythymidine and 2′, 3′-dideoxynucleosides inhibit DNA polymerase γ by different mechanisms. Biochm. Biophys. Res. Commun. 179(2), 776-783 (1991).

    4. Li, Y., Mitaxov, V., and Waksman, G. Structure-based design of Taq DNA polymerases with improved properties of dideoxynucleotide incorporation. Proc. Natl. Acad. Sci. USA 96(17), 9491-9496 (1999).