A TRPM2 agonist
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2'-deoxy NAD+ (sodium salt)

Item No. 38386

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2'-deoxy-adenosine 5'-(trihydrogen diphosphate), P′→5′-ester with 3-(aminocarbonyl)-1-β-D-ribofuranosylpyridinium, inner salt, monosodium salt
CAS Number
1514900-83-4
Synonyms
  • 2'-deoxy Nicotinamide adenine dinucleotide
Molecular Formula
C21H26N7O13P2 • Na
Formula Weight
669.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O[C@H]([C@@H]1O)[C@H]([N+]2=CC(C(N)=O)=CC=C2)O[C@@H]1COP([O-])(OP([O-])(OC[C@H]([C@H](C3)O)O[C@H]3N4C=NC5=C(N)N=CN=C54)=O)=O.[Na+]
InChi Code
InChI=1S/C21H27N7O13P2.Na/c22-18-15-20(25-8-24-18)28(9-26-15)14-4-11(29)12(39-14)6-37-42(33,34)41-43(35,36)38-7-13-16(30)17(31)21(40-13)27-3-1-2-10(5-27)19(23)32;/h1-3,5,8-9,11-14,16-17,21,29-31H,4,6-7H2,(H5-,22,23,24,25,32,33,34,35,36);/q;+1/p-1/t11-,12+,13+,14+,16+,17+,21+;/m0./s1
InChi Key
KURUHDGFKRYFCS-SUWCGJJBSA-M
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    600 µg

    $415

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    Product Description

    2'-deoxy NAD+ is a transient receptor potential melastatin 2 (TRPM2) agonist.1 It increases calcium-induced currents in an inside-out patch clamp assay using HEK293 cells expressing human TRPM2 when used at a concentration of 30 µM. 2'-deoxy NAD+ has been found in Jurkat T cells. It also is a substrate of poly(ADP-ribose) transferases (PARPs) for the ADP-ribosylation of non-histone proteins in nuclei isolated from HeLa cells and rat livers.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fliegert, R., Bauche, A., Pérez, A.-M.W., et al. 2'-Deoxyadenosine 5'-diphosphoribose is an endogenous TRPM2 superagonist. Nat. Chem. Biol. 13(9), 1036-1044 (2017).

    2. Lichtenwalner, D.M., and Suhadolnik, R.J. Adenosine diphosphate ribosylation of histone and nonhistone chromosomal proteins with oxidized nicotinamide adenine dinucleotide and 2'-deoxynicotinamide adenine dinucleotide using nuclei isolated from rat liver and HeLa cells. Biochemistry 18(17), 3749-3755 (1978).