A phenol with diverse biological activities
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Hispolon

Item No. 38415

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-(3,4-dihydroxyphenyl)-4-hydroxy-3Z,5E-hexadien-2-one
CAS Number
173933-40-9
Molecular Formula
C12H12O4
Formula Weight
220.0
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetone: SolubleMethanol: Soluble
SMILES
O=C(C)/C=C(O)/C=C/C1=CC(O)=C(C=C1)O
InChi Code
InChI=1S/C12H12O4/c1-8(13)6-10(14)4-2-9-3-5-11(15)12(16)7-9/h2-7,14-16H,1H3/b4-2+,10-6-
InChi Key
QDVIEIMMEUCFMW-QXYPORFMSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $109

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    10 mg

    $196

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    25 mg

    $464

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    50 mg

    $763

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    Cayman Chemical
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    Product Description

    Hispolon is a phenol originally isolated from I. hispidus that has diverse biological activities.1,2,3 It scavenges superoxide and hydroxyl radicals in cell-free assays, as well as reduces LPS-induced production of reactive oxygen species (ROS) in RAW 264.7 cells when used at concentrations of 5 and 10 µM.2 Hispolon (60-80 µM) inhibits cell proliferation and induces apoptosis in C6 rat glioma and DBTRG-05MG human glioblastoma cells.1 Hispolon (5 and 10 mg/kg) reduces tumor volume in a DBTRG-05MG mouse xenograft model. It also reduces acetic acid-induced writhing in mice when administered at a dose of 20 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liao, K.-F., Chiu, T.-L., Chang, S.-F., et al. Hispolon induces apoptosis, suppresses migration and invasion of glioblastoma cells and inhibits gbm xenograft tumor growth in vivo. Molecules 26(15), 4497 (2021).

    2. Lee, E.K., Koh, E.M., Kim, Y.N., et al. Immunomodulatory effect of hispolon on LPS-induced RAW264.7 cells and mitogen/alloantigen-stimulated spleen lymphocytes of mice. Pharmaceutics 14(7), 1423 (2022).

    3. Chang, H.-Y., Sheu, M.-J., Yang, C.-H., et al. Analgesic effects and the mechanisms of anti-inflammation of hispolon in mice. Evid. Based Complement. Alternat. Med. 2011, 478246 (2009).