A GPX4 inhibitor
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

GPX4 24

Item No. 38428

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1S,3R)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methylsulfonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylic acid, methyl ester
CAS Number
2920221-53-8
Synonyms
  • Glutathione Peroxidase 4 24
  • PHGPx 24
  • Phospholipid Hydroperoxide Glutathione Peroxidase 24
Molecular Formula
C22H21ClN2O5S
Formula Weight
460.9
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 20 mg/ml
λmax
222 nm
SMILES
ClCC(N1[C@H](CC(C2=CC=CC=C2N3)=C3[C@@H]1C4=CC=C(C=C4)S(C)(=O)=O)C(OC)=O)=O
InChi Code
InChI=1S/C22H21ClN2O5S/c1-30-22(27)18-11-16-15-5-3-4-6-17(15)24-20(16)21(25(18)19(26)12-23)13-7-9-14(10-8-13)31(2,28)29/h3-10,18,21,24H,11-12H2,1-2H3/t18-,21+/m1/s1
InChi Key
GONRCSSWFFDKDJ-NQIIRXRSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $74

    Add

    5 mg

    $311

    Add

    10 mg

    $585

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    GPX4 24 is an inhibitor of glutathione peroxidase 4 (GPX4) and a derivative of (1S,3R)-RSL3 (Item No. 19288).1 It covalently binds to GPX4 in 4T1 murine mammary carcinoma cells in a concentration-dependent manner. GPX4 24 induces ferroptosis in GPX4-dependent HT-1080 fibrosarcoma cells (EC50 = 0.16 µM). It increases kidney and plasma malondialdehyde (MDA) levels in mice when administered at a dose of 200 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Randolph, J.T., O'Connor, M.J., Han, F., et al. Discovery of a potent chloroacetamide GPX4 inhibitor with bioavailability to enable target engagement in mice, a potential tool compound for inducing ferroptosis in vivo. J. Med. Chem. 66(6), 3852-3865 (2023).