A GPX4 inhibitor
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GPX4 24

Item No. 38428

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1S,3R)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methylsulfonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylic acid, methyl ester
CAS Number
2920221-53-8
Synonyms
  • Glutathione Peroxidase 4 24
  • PHGPx 24
  • Phospholipid Hydroperoxide Glutathione Peroxidase 24
Molecular Formula
C22H21ClN2O5S
Formula Weight
460.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 20 mg/ml
λmax
222 nm
SMILES
ClCC(N1[C@H](CC(C2=CC=CC=C2N3)=C3[C@@H]1C4=CC=C(C=C4)S(C)(=O)=O)C(OC)=O)=O
InChi Code
InChI=1S/C22H21ClN2O5S/c1-30-22(27)18-11-16-15-5-3-4-6-17(15)24-20(16)21(25(18)19(26)12-23)13-7-9-14(10-8-13)31(2,28)29/h3-10,18,21,24H,11-12H2,1-2H3/t18-,21+/m1/s1
InChi Key
GONRCSSWFFDKDJ-NQIIRXRSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    GPX4 24 is an inhibitor of glutathione peroxidase 4 (GPX4) and a derivative of (1S,3R)-RSL3 (Item No. 19288).1 It covalently binds to GPX4 in 4T1 murine mammary carcinoma cells in a concentration-dependent manner. GPX4 24 induces ferroptosis in GPX4-dependent HT-1080 fibrosarcoma cells (EC50 = 0.16 µM). It increases kidney and plasma malondialdehyde (MDA) levels in mice when administered at a dose of 200 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Randolph, J.T., O'Connor, M.J., Han, F., et al. Discovery of a potent chloroacetamide GPX4 inhibitor with bioavailability to enable target engagement in mice, a potential tool compound for inducing ferroptosis in vivo. J. Med. Chem. 66(6), 3852-3865 (2023).