A fluorescent dGTP derivative
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2'-Deoxy-3'-O-(N'-methylanthraniloyl)guanosine-5'-O-triphosphate (sodium salt)

Item No. 38459

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2′-deoxy-3′-[2-(methylamino)benzoate] guanosine 5′-(tetrahydrogen triphosphate), tetrasodium salt
Synonyms
  • 2’-deoxy-3’-MANT-GTP
  • MANT-dGTP
Molecular Formula
C18H19N6O14P3 • 4Na
Formula Weight
728.3
Purity
≥95%
Formulation (Request formulation change)
A solution in water
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O=P(OP([O-])([O-])=O)([O-])OP(OC[C@H]1O[C@@H](N2C=NC3=C2NC(N)=NC3=O)C[C@@H]1OC(C4=C(NC)C=CC=C4)=O)([O-])=O.[Na+].[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C18H23N6O14P3.4Na/c1-20-10-5-3-2-4-9(10)17(26)36-11-6-13(24-8-21-14-15(24)22-18(19)23-16(14)25)35-12(11)7-34-40(30,31)38-41(32,33)37-39(27,28)29;;;;/h2-5,8,11-13,20H,6-7H2,1H3,(H,30,31)(H,32,33)(H2,27,28,29)(H3,19,22,23,25);;;;/q;4*+1/p-4/t11-,12+,13+;;;;/m0..../s1
InChi Key
IJGIXBLNLKCYNH-NDASMTADSA-J
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    3.2 mg

    $248

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    Product Description

    2'-Deoxy-3'-O-(N'-methylanthraniloyl)guanosine-5'-O-triphosphate (2’-deoxy-3’-MANT-GTP) is a fluorescent derivative of dGTP (Item No. 35771).1,2,3 It selectively inhibits recombinant mammalian adenylyl cyclase 1 (AC1), AC2, AC5, and AC6 (Kis = 260, 1,200, 420, and 470 nM, respectively), bovine lung soluble guanylyl cyclase (sGC; Ki = 220 nM), and B. anthracis edema factor AC toxin (Ki = 630 nM) over rat testis soluble AC (sAC) and B. pertussis AC toxin (Kis = 43 and 14 µM, respectively).1 2’-deoxy-3’-MANT-GTP has been used to study the activity of various GTPases, including elongation factor Tu (EF-Tu) and H-Ras p21.2,3 A related derivative, 2'(3')-MANT-GTP (Item No. 38469), displays an emission maximum of 442 nm upon excitation at 350 nm.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gille, A., Lushington, G.H., Mou, T.-C., et al. Differential inhibition of adenylyl cyclase isoforms and soluble guanylyl cyclase by purine and pyrimidine nucleotides. The Journal of Biological Chemisty 279(19), 19955-19969 (2004).

    2. Rodina, M.V., Fricke, R., Kuhn, L., et al. Codon-dependent conformational change of elongation factor Tu preceding GTP hydrolysis on the ribosome. EMBO J. 14(11), 2613-2619 (1995).

    3. John, J., Sohmen, R., Feuerstein, J., et al. Kinetics of interaction of nucleotides with nucleotide-free H-ras p21. Biochemistry 29(25), 6058-6065 (1990).

    4. Hiratsuka, T. New ribose-modified fluorescent analogs of adenine and guanine nucleotides available as substrates for various enzymes. Biochim. Biophys. Acta 742(3), 496-508 (1983).