A sulfur-containing nucleoside triphosphate
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2',3'-Dideoxyadenosine-5'-O-(1-thiotriphosphate) (sodium salt)

Item No. 38460

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2′,3′-dideoxy-adenosine, 5′→P′′-ester with thiotriphosphoric acid ((HO)2P(O)OP(O)(OH)OP(O)(OH)(SH)), tetrasodium salt
Synonyms
  • ddATP-α-S
  • α‐S‐ddATP
Molecular Formula
C10H12N5O10P3S • 4Na
Formula Weight
579.2
Purity
≥95% (a mixture of Rp and Sp isomers)
Formulation (Request formulation change)
A solution in water
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
NC1=C(N=C2)C(N2[C@H]3CC[C@@H](COP(OP(OP([O-])([O-])=O)([O-])=O)([S-])=O)O3)=NC=N1.[Na+].[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C10H16N5O10P3S.4Na/c11-9-8-10(13-4-12-9)15(5-14-8)7-2-1-6(23-7)3-22-28(21,29)25-27(19,20)24-26(16,17)18;;;;/h4-7H,1-3H2,(H,19,20)(H,21,29)(H2,11,12,13)(H2,16,17,18);;;;/q;4*+1/p-4/t6-,7+,28?;;;;/m0..../s1
InChi Key
XHGOPPWSTWXSKT-HAGVXKASSA-J
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    2.5 mg

    $415

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    Product Description

    2',3'-Dideoxyadenosine-5'-O-(1-thiotriphosphate) (ddATP-α-S) is a sulfur-containing nucleoside triphosphate derivative. Thiol-containing dideoxynucleoside triphosphates (α-S-ddNTPs) incorporated into allele-specific primers prevent complete digestion by 5’-phosphodiesterase, which allows for alkylation and identification of SNP-containing alleles.1 ddATP-α-S has been used for chain extension in PCR assays.2 ddATP-α-S is a mixture of Rp and Sp isomers.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sauer, S., Lechner, D., Berlin, K.D., et al. A novel procedure for efficient genotyping of single nucleotide polymorphisms. Nucleic Acids Res. 28(5), E13 (2000).

    2. Sauer, S., Lehrach, H., and Reinhardt, R. MALDI mass spectrometry analysis of single nucleotide polymorphisms by photocleavage and charge-tagging. Nucleic Acids Res. 31(11), e63 (2003).